Detailed information of TA system TA183164

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3652594..3653263
• Replicon: chromosome
• Accession: NZ_CP065673
• Organism: Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: S4YKD8
• Locus tag: I6G64_RS17105
• Protein ID: WP_006327725.1
• Coordinates: 3652841..3653263 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S4YS10
• Locus tag: I6G64_RS17100
• Protein ID: WP_004952428.1
• Coordinates: 3652594..3652860 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G64_RS17075	3647718..3649043	+	1326	WP_063200124.1	MHS family MFS transporter	-
I6G64_RS17080	3649093..3649701	-	609	WP_013814383.1	HD domain-containing protein	-
I6G64_RS17085	3649892..3650569	+	678	WP_004952439.1	hemolysin III family protein	-
I6G64_RS17090	3650732..3651229	+	498	WP_063200127.1	DUF2165 domain-containing protein	-
I6G64_RS17095	3651283..3652269	-	987	WP_063200130.1	tRNA-modifying protein YgfZ	-
I6G64_RS17100	3652594..3652860	+	267	WP_004952428.1	FAD assembly factor SdhE	Antitoxin
I6G64_RS17105	3652841..3653263	+	423	WP_006327725.1	protein YgfX	Toxin
I6G64_RS17110	3653263..3653958	+	696	WP_062868495.1	two-component system response regulator CreB	-
I6G64_RS17115	3653955..3655373	+	1419	WP_063200132.1	two-component system sensor histidine kinase CreC	-
I6G64_RS17120	3655458..3656822	+	1365	WP_063200135.1	cell envelope integrity protein CreD	-
I6G64_RS17125	3656860..3657378	-	519	WP_004952413.1	flavodoxin FldB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16461.41 Da
• Isoelectric Point: 11.0260

>T183164 WP_006327725.1 NZ_CP065673:3652841-3653263 [Serratia plymuthica]
VAQWRCNVRISWRTQLLSLLTHGVLILLILISPWPEGYGPIWLVLLTLVVFECIRSQKRIASRQGELRLLANKRLSWHGQ
EWLLAKQPWMPRYGILLTLQPTQGKKRRRLWLASDSMGKAEWRHLRQLLLHPSADDDEEP

Nucleotide

• Length: 423 bp

>T183164 NZ_CP086726:1668876-1669217 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGGCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10446.90 Da
• Isoelectric Point: 5.0843

>AT183164 WP_004952428.1 NZ_CP065673:3652594-3652860 [Serratia plymuthica]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDQLNDTDKALFIRLLESDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT183164 NZ_CP086726:1668646-1668876 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCGGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Structures

Toxin

• AlphaFold DB: S4YKD8

Antitoxin

• AlphaFold DB: S4YS10