Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-parD/RelE(toxin)
Location 3000130..3000695 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4V4R7
Locus tag I6G64_RS14190 Protein ID WP_063200583.1
Coordinates 3000130..3000408 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A2X4VH61
Locus tag I6G64_RS14195 Protein ID WP_062868918.1
Coordinates 3000426..3000695 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G64_RS14170 2996295..2996633 - 339 WP_041416656.1 PTS lactose/cellobiose transporter subunit IIA -
I6G64_RS14175 2996990..2997559 + 570 WP_062868920.1 peptidylprolyl isomerase A -
I6G64_RS14180 2997719..2999404 + 1686 WP_197913203.1 sensor histidine kinase -
I6G64_RS14185 2999404..3000129 + 726 WP_197913204.1 two-component system response regulator BtsR -
I6G64_RS14190 3000130..3000408 - 279 WP_063200583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G64_RS14195 3000426..3000695 - 270 WP_062868918.1 hypothetical protein Antitoxin
I6G64_RS14200 3000925..3002451 + 1527 WP_037433749.1 DUF853 family protein -
I6G64_RS14205 3002557..3003132 + 576 WP_006328493.1 aminodeoxychorismate synthase component II -
I6G64_RS14210 3003264..3004481 + 1218 WP_062868917.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10260.87 Da        Isoelectric Point: 8.5141

>T183163 WP_063200583.1 NZ_CP065673:c3000408-3000130 [Serratia plymuthica]
VTLKWTEPAIADRMAIYDYLETKNPAAAIEIDSLISATATRLSQNPSSGKPGRVPGTREMVIHHSYFLVYELINGLIIML
AVVHARRQWPAN

Download         Length: 279 bp

>T183163 NZ_CP086726:c1662475-1662332 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10352.65 Da        Isoelectric Point: 7.0169

>AT183163 WP_062868918.1 NZ_CP065673:c3000695-3000426 [Serratia plymuthica]
MSESTVVIRVDEELKIAFASAAKAADRTASQLLRDFMRDFVSRQTHQKEYEQWLQEKVDLSRKALNEGKITDNEAVEAYF
AERRSKLTR

Download         Length: 270 bp

>AT183163 NZ_CP086726:c1662188-1662139 [Enterococcus faecalis]
AATAAAAATGCCCGAGCCTTAGAAAAATAAGAGGCTCGGGCATTTTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4V4R7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4VH61

References