Detailed information of TA system TA183162

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2396573..2397046
• Replicon: chromosome
• Accession: NZ_CP065673
• Organism: Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I6G64_RS11500
• Protein ID: WP_063202450.1
• Coordinates: 2396573..2396848 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X4TR66
• Locus tag: I6G64_RS11505
• Protein ID: WP_062869225.1
• Coordinates: 2396849..2397046 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G64_RS11485	2391617..2391994	-	378	WP_063202448.1	AprI/Inh family metalloprotease inhibitor	-
I6G64_RS11490	2392050..2393513	-	1464	WP_062869227.1	serralysin family metalloprotease	-
I6G64_RS11495	2394196..2396512	+	2317	Protein_2234	zinc/cadmium/mercury/lead-transporting ATPase	-
I6G64_RS11500	2396573..2396848	-	276	WP_063202450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I6G64_RS11505	2396849..2397046	-	198	WP_062869225.1	hypothetical protein	Antitoxin
I6G64_RS11510	2397107..2397352	-	246	WP_004950955.1	sulfurtransferase TusA	-
I6G64_RS11515	2397573..2398238	+	666	WP_006323048.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
I6G64_RS11520	2398281..2398715	+	435	WP_063202452.1	GNAT family N-acetyltransferase	-
I6G64_RS11525	2398796..2399359	+	564	WP_004950949.1	DcrB family lipoprotein	-
I6G64_RS11530	2399408..2400607	-	1200	WP_063202454.1	anaerobic glycerol-3-phosphate dehydrogenase subunit C	-
I6G64_RS11535	2400604..2401857	-	1254	WP_063202456.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10660.56 Da
• Isoelectric Point: 11.2606

>T183162 WP_063202450.1 NZ_CP065673:c2396848-2396573 [Serratia plymuthica]
MLVIEWSRSARQDLADILLFIANDNPRAARKMKVLISEAILPAAEHPHIFRRGRVDGTHEIIVHPNYLLIYQVVADRIRV
MRVLHARRRYP

Nucleotide

• Length: 276 bp

>T183162 NZ_CP086726:1401396-1402034 [Enterococcus faecalis]
ATGATACTTAATAAGAAAAAATTATATTTCGAAACACAGGCATTTACTGACAAACTTATAAATGAAATTTCAATCAATAT
GTCTAAAAGAAAAGAACTCATCAATTGTTATGATATTGAAGCCTACGTAAAAGAAACCGAAAACATTGATTTTTTTGATT
ATCCATTCAAAAAACAATCTAAAAAATTAATCTGGGGATCAGTAACAAAAATTGGTGATGTAACTATGGTAGCGACTGCC
CAACACTTGAAAATAGAAATTAAAAATTTTACGAAAATGCACGAAATAATTCATCATTATTTTGACTATACGACAGATAT
ACCTAACAATGAAAAATCATTTGATACACTACTTATAAAAAAGGGCTATCTTCCTGAAGATTATCCTAAAGAATTCAGAG
CAAATAAGGGTGCCGGAATGTTACTTATTAATAAAAAAGCCTTAAAGTATGCATTTAGTACTTATGATGATCTTGAAAAA
ATGGCTAGTTTTTTCAACGTAAACGATATAGTTCTCAAGATAAGAATTCTTGACGAATTAATCTATTCCCACAACTTATC
TTATAAACAAGCCAATCTTATTTATAATAGTTACTATTTTCAACAACAAACACAACTTAAAGAGATTTTATTCAAATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7580.65 Da
• Isoelectric Point: 4.4488

>AT183162 WP_062869225.1 NZ_CP065673:c2397046-2396849 [Serratia plymuthica]
MVILRSPVVSEYETQEQTEIYDRWFREKVREAMDDPLPGISHDEVMAEMDALIAVAEARKKTKQV

Nucleotide

• Length: 198 bp

>AT183162 NZ_CP086726:1401015-1401389 [Enterococcus faecalis]
ATGAAAACTTACGAAAAGATAAAACAATTAAGAGAAAATAGAGAAATCACTCAAAAAGAAATTTCAAACGCACTAGACAT
TAATGTTAGTGTATATAATAAAATAGAACTTGGAATACGTCCATTAAGAGAAGAAGAACTTACTGCTATTGCTGATTTTT
TTAATGTTTCAATTGATTATTTAACAGGACGCACTGATAACCCTACAACACCTTCAAATAATCAAAAAGAAGCTGGACAA
AATATTATTTCACATTTCAGATTAAACACTAATGATTTAAGTTCTGATGACATAGAAGAATTAGAAAAAGAATTGATTGA
TTTTCAAGAATTTCTTATAAAACGAGCAAAAGAAAGAAAAAAAAAGAGTGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2X4TR66