Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2094425..2094952 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name relE Uniprot ID A0A2X4X2J1
Locus tag I6G64_RS10005 Protein ID WP_063202072.1
Coordinates 2094425..2094700 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6G64_RS10010 Protein ID WP_063202252.1
Coordinates 2094704..2094952 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G64_RS09965 2090133..2090513 - 381 WP_073972075.1 hypothetical protein -
I6G64_RS09970 2090585..2091004 - 420 WP_063202090.1 hypothetical protein -
I6G64_RS09975 2091019..2091399 - 381 WP_073972074.1 hypothetical protein -
I6G64_RS09980 2091581..2091961 - 381 WP_063202083.1 hypothetical protein -
I6G64_RS09985 2091958..2092479 - 522 WP_063202080.1 hypothetical protein -
I6G64_RS09990 2092818..2093138 - 321 WP_063202076.1 hypothetical protein -
I6G64_RS09995 2093135..2093272 - 138 WP_155729010.1 hypothetical protein -
I6G64_RS10000 2093576..2094211 - 636 WP_013811336.1 carbonic anhydrase -
I6G64_RS10005 2094425..2094700 - 276 WP_063202072.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G64_RS10010 2094704..2094952 - 249 WP_063202252.1 ribbon-helix-helix domain-containing protein Antitoxin
I6G64_RS10015 2095225..2095454 - 230 Protein_1958 integrase -
I6G64_RS10020 2096042..2096305 + 264 WP_063202070.1 type II toxin-antitoxin system HigB family toxin -
I6G64_RS10025 2096302..2097531 + 1230 WP_063202067.1 ImmA/IrrE family metallo-endopeptidase -
I6G64_RS10030 2097545..2098678 + 1134 WP_063202064.1 beta family protein -
I6G64_RS10035 2098859..2099248 - 390 WP_063202061.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2083797..2108068 24271


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-44)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11041.48 Da        Isoelectric Point: 5.1450

>T183161 WP_063202072.1 NZ_CP065673:c2094700-2094425 [Serratia plymuthica]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLIIGSAGLTMHPAIGIQQTRYEPREVRKVLFDDYEVHYELRDNAIY
IVDLWHTKEER

Download         Length: 276 bp

>T183161 NZ_CP086726:1197346-1197441 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGCTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9048.37 Da        Isoelectric Point: 7.2042

>AT183161 WP_063202252.1 NZ_CP065673:c2094952-2094704 [Serratia plymuthica]
MGSLTKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTRMLAESERRHQSIQTGLADVDAGRVVSHSDMVDFANRLK
KT

Download         Length: 249 bp

>AT183161 NZ_CP086726:c1197540-1197476 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4X2J1

Antitoxin

Source ID Structure

References