Detailed information of TA system TA183160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2087620..2089169
• Replicon: chromosome
• Accession: NZ_CP065673
• Organism: Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2X4X2K0
• Locus tag: I6G64_RS09950
• Protein ID: WP_063202100.1
• Coordinates: 2087620..2088918 (-)
• Length: 433 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6G64_RS09955
• Protein ID: WP_004953056.1
• Coordinates: 2088921..2089169 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G64_RS09925	2082804..2083616	-	813	WP_063202113.1	HNH endonuclease	-
I6G64_RS09930	2083930..2084022	+	93	Protein_1941	ash family protein	-
I6G64_RS09935	2084065..2084382	+	318	WP_063202107.1	hypothetical protein	-
I6G64_RS09940	2084556..2085536	-	981	WP_063202103.1	DUF4928 family protein	-
I6G64_RS09945	2085536..2086801	-	1266	WP_073972076.1	DNA (cytosine-5-)-methyltransferase	-
I6G64_RS09950	2087620..2088918	-	1299	WP_063202100.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6G64_RS09955	2088921..2089169	-	249	WP_004953056.1	helix-turn-helix domain-containing protein	Antitoxin
I6G64_RS09960	2089376..2090077	-	702	WP_063202097.1	hypothetical protein	-
I6G64_RS09965	2090133..2090513	-	381	WP_073972075.1	hypothetical protein	-
I6G64_RS09970	2090585..2091004	-	420	WP_063202090.1	hypothetical protein	-
I6G64_RS09975	2091019..2091399	-	381	WP_073972074.1	hypothetical protein	-
I6G64_RS09980	2091581..2091961	-	381	WP_063202083.1	hypothetical protein	-
I6G64_RS09985	2091958..2092479	-	522	WP_063202080.1	hypothetical protein	-
I6G64_RS09990	2092818..2093138	-	321	WP_063202076.1	hypothetical protein	-
I6G64_RS09995	2093135..2093272	-	138	WP_155729010.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2083797..2108068	24271

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (3-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 433 a.a.
• Molecular weight: 48251.25 Da
• Isoelectric Point: 6.1874

>T183160 WP_063202100.1 NZ_CP065673:c2088918-2087620 [Serratia plymuthica]
VDKLRVALNGTVVGTLEKHAGGAMSFVYHEEWLAQAGARAISLSLPLQPEPFRGDVVYNFFDNLLPDSEFIRSRLQARFR
TATKQPFDLLSSIGSDCVGAIQLYPEHADMAPVKQVNAVPVSDEEIEQLLLGYREAPLGMVAGTDDFRISLAGAQEKTAL
LWFGNQWYRPQGSTPTSHIIKLPIGHIAHNNLDLSESCENEWLCLRIAEQFGLPVAQAELARFGEQKVLIVERFDRRWAR
DNSWLIRLPQEDFCQALGIAPALKYEADGGPGIAAAMQLLMGSQQPLLDRDTFFKSQIVFWMLAAIDGHAKNFSLFIEQE
TAYRMTPLYDVLSGYPFMHARGIAPQKTKMAMAAIGKGRHYRWSQILPRHFISTARAVGYSEEKTLQVMADLKAQTEQAI
ANVEAMLPDEFPRSVSDAIFSGVRRQAERLLG

Nucleotide

• Length: 1299 bp

>T183160 NZ_CP086726:c1044516-1044406 [Enterococcus faecalis]
TTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTTAGCGCT
TGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9263.60 Da
• Isoelectric Point: 10.4887

>AT183160 WP_004953056.1 NZ_CP065673:c2089169-2088921 [Serratia plymuthica]
MKITSAKMLAHALRNERKKRNQSQSKTADSIGLKQATVSAFENNPDGTRLETLFKLLAALDLELQVTPRGKPVDPKTWDQ
EW

Nucleotide

• Length: 249 bp

>AT183160 NZ_CP086726:1044290-1044495 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACCAGTTATAAGAACTGGTGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Structures

Toxin

• AlphaFold DB: A0A2X4X2K0