183159

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1699909..1700465 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name parE Uniprot ID A0A2X4UAE5
Locus tag I6G64_RS08130 Protein ID WP_063202630.1
Coordinates 1700175..1700465 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4TZF9
Locus tag I6G64_RS08125 Protein ID WP_063202628.1
Coordinates 1699909..1700187 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G64_RS08100 1695250..1696089 - 840 WP_006323781.1 MurR/RpiR family transcriptional regulator -
I6G64_RS08105 1696234..1697820 + 1587 WP_063202668.1 gamma-glutamyltransferase -
I6G64_RS08110 1697845..1698036 + 192 WP_006322394.1 oxalurate catabolism protein HpxX -
I6G64_RS08115 1698033..1699433 + 1401 WP_063202626.1 AtzE family amidohydrolase -
I6G64_RS08120 1699437..1699823 + 387 WP_004949013.1 oxalurate catabolism protein HpxZ -
I6G64_RS08125 1699909..1700187 + 279 WP_063202628.1 CopG family ribbon-helix-helix protein Antitoxin
I6G64_RS08130 1700175..1700465 + 291 WP_063202630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G64_RS08135 1700475..1701359 - 885 WP_063202632.1 siderophore-interacting protein -
I6G64_RS08140 1701365..1702588 - 1224 WP_063202634.1 MFS transporter -
I6G64_RS08145 1702726..1704471 + 1746 WP_063202637.1 aerobactin synthase IucA -
I6G64_RS08150 1704468..1705418 + 951 WP_063202639.1 acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10904.65 Da        Isoelectric Point: 9.5469

>T183159 WP_063202630.1 NZ_CP065673:1700175-1700465 [Serratia plymuthica]
VPQLIWTPAALLDVQQLYRFLAEKDLNSAKRAVATIRNCIKIIAHQPHIGRPAKDMAPEFREWPIDFGNSGYLVLYRFNG
VTAVILAIRHQSETGY

Download         Length: 291 bp

>T183159 NZ_CP086726:c731017-730742 [Enterococcus faecalis]
ATGCTTGAAATATTTTACACGAACCAATTCAAAAAAGACTTTAAGAAAGCAAAGAAACAAGGAAAGAATTTAGAGAAGTT
AAAAGAAGTATTAGTACTTTTACAAGAACAGCAAACATTGCCGCCAAAGTATAAAGACCACGCACTAACAGGAAATTATA
TAGGTACAAGAGAGTGCCATATTGAACCAGATTGGTTACTGATTTATAAAATTGACGGTGATAAATTGATCCTAACTTTA
GCTCGAATAGGCTCACATAGTGAATTATTTCGATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10649.73 Da        Isoelectric Point: 5.5193

>AT183159 WP_063202628.1 NZ_CP065673:1699909-1700187 [Serratia plymuthica]
MATATSIKIDDELKQRVQHIAAAHQRSAHWIMREAIREYVEREEKREAVRNDALQAWETYQANGKHLTQHEADGWLSDLE
KGDDTEIPGCHN

Download         Length: 279 bp

>AT183159 NZ_CP086726:c731276-731010 [Enterococcus faecalis]
GTGGCTACTACAAAAAAGAAACCTATACATGTAAATGTTGATGAAAATTTAAAAGAAGAAGCAGAACAATTATTTGATGA
TTTAGGGTTAAATATGACAAGTGCAATTACGATTTTCTTAAAACAGTCTATTAATGAGCAAGCAATTCCTTTTATGATTA
ATAAGGGAAACAAAGAGACTCTACAAGCATTAAAAGACATTAAAGAAGGAAATGTTCATGGTGGATTTTCTTCCGTGGAG
GATTTAATGGAGGATTTAAATGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4UAE5

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4TZF9

References