Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1456099..1456721 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name Hha Uniprot ID S4YCZ4
Locus tag I6G64_RS06970 Protein ID WP_006322256.1
Coordinates 1456518..1456721 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S4YKH5
Locus tag I6G64_RS06965 Protein ID WP_004949348.1
Coordinates 1456099..1456467 (+) Length 123 a.a.

Genomic Context

I6G64_RS06935I6G64_RS06940I6G64_RS06960I6G64_RS06965I6G64_RS06970I6G64_RS06985I6G64_RS06945I6G64_RS06950I6G64_RS06955I6G64_RS06975I6G64_RS06980I6G64_RS06990I6G64_RS06995
Location: 1452140..1452394 (255 bp)
Type: Others
Protein ID: WP_004949355.1
Location: 1452407..1452547 (141 bp)
Type: Others
Protein ID: WP_004949353.1
Location: 1455586..1455939 (354 bp)
Type: Others
Protein ID: WP_063198033.1
Location: 1456099..1456467 (369 bp)
Type: Antitoxin
Protein ID: WP_004949348.1
Location: 1456518..1456721 (204 bp)
Type: Toxin
Protein ID: WP_006322256.1
Location: 1459260..1459634 (375 bp)
Type: Others
Protein ID: WP_063198035.1
Location: 1452663..1453541 (879 bp)
Type: Others
Protein ID: WP_063198026.1
Location: 1453567..1454424 (858 bp)
Type: Others
Protein ID: WP_063198028.1
Location: 1454421..1455134 (714 bp)
Type: Others
Protein ID: WP_062869870.1
Location: 1456962..1457498 (537 bp)
Type: Others
Protein ID: WP_006323971.1
Location: 1457559..1458980 (1422 bp)
Type: Others
Protein ID: WP_062869867.1
Location: 1459631..1460461 (831 bp)
Type: Others
Protein ID: WP_073972022.1
Location: 1460494..1460955 (462 bp)
Type: Others
Protein ID: WP_063198037.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6G64_RS069351452140..1452394+255WP_004949355.1type B 50S ribosomal protein L31-
I6G64_RS069401452407..1452547+141WP_004949353.1type B 50S ribosomal protein L36-
I6G64_RS069451452663..1453541-879WP_063198026.1metal ABC transporter substrate-binding protein-
I6G64_RS069501453567..1454424-858WP_063198028.1metal ABC transporter permease-
I6G64_RS069551454421..1455134-714WP_062869870.1ABC transporter ATP-binding protein-
I6G64_RS069601455586..1455939+354WP_063198033.1hypothetical protein-
I6G64_RS069651456099..1456467+369WP_004949348.1Hha toxicity modulator TomBAntitoxin
I6G64_RS069701456518..1456721+204WP_006322256.1hemolysin expression modulator HhaToxin
I6G64_RS069751456962..1457498-537WP_006323971.1cytochrome b/b6 domain-containing protein-
I6G64_RS069801457559..1458980-1422WP_062869867.1N-acetylglucosamine-binding protein GbpA-
I6G64_RS069851459260..1459634+375WP_063198035.1type II secretion system pilot lipoprotein GspS-
I6G64_RS069901459631..1460461-831WP_073972022.1A24 family peptidase-
I6G64_RS069951460494..1460955-462WP_063198037.1type II secretion system protein M-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1455613..147241716804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8085.45 Da        Isoelectric Point: 6.9764

>T183158 WP_006322256.1 NZ_CP065673:1456518-1456721 [Serratia plymuthica]
MTKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVAVWKFVR

Download         Length: 204 bp

>T183158 NZ_CP086725:56280-56762 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14203.92 Da        Isoelectric Point: 4.5140

>AT183158 WP_004949348.1 NZ_CP065673:1456099-1456467 [Serratia plymuthica]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEGICTTMKT

Download         Length: 369 bp

>AT183158 NZ_CP086725:56026-56292 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGTCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCTGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1B1KM53

Antitoxin

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Source
ID
Structure
AlphaFold DBS4YKH5

References