183157

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 946989..947545 Replicon chromosome
Accession NZ_CP065673
Organism Serratia plymuthica strain FDAARGOS_907

Toxin (Protein)


Gene name ccdB Uniprot ID A0A7U4DW07
Locus tag I6G64_RS04450 Protein ID WP_013812173.1
Coordinates 946989..947306 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A2X4U7C9
Locus tag I6G64_RS04455 Protein ID WP_063199959.1
Coordinates 947309..947545 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G64_RS04430 942760..943917 - 1158 WP_062870253.1 YbfB/YjiJ family MFS transporter -
I6G64_RS04435 944025..944942 + 918 WP_063199956.1 LysR family transcriptional regulator -
I6G64_RS04440 944971..946098 + 1128 WP_062870249.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
I6G64_RS04445 946113..946955 + 843 WP_004942338.1 S-formylglutathione hydrolase -
I6G64_RS04450 946989..947306 - 318 WP_013812173.1 CcdB family protein Toxin
I6G64_RS04455 947309..947545 - 237 WP_063199959.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6G64_RS04460 947690..948598 - 909 WP_174523958.1 glutathione ABC transporter permease GsiD -
I6G64_RS04465 948608..949528 - 921 WP_062870247.1 glutathione ABC transporter permease GsiC -
I6G64_RS04470 949581..951119 - 1539 WP_004942332.1 glutathione ABC transporter substrate-binding protein GsiB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11972.92 Da        Isoelectric Point: 5.8267

>T183157 WP_013812173.1 NZ_CP065673:c947306-946989 [Serratia plymuthica]
MQFTVYANTGKSAVYPLLLDVTNDIIEQLNRRVMIPLLPIEKYPASTRPERLNPLVRLVDDNEYAVMTHEMASIPVRILG
AEFCDASQYRTKVKAAIDFLFDGIR

Download         Length: 318 bp

>T183157 NZ_CP086725:11346-11762 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9152.24 Da        Isoelectric Point: 6.7189

>AT183157 WP_063199959.1 NZ_CP065673:c947545-947309 [Serratia plymuthica]
MPVKQRTTQSVTMAVERSLLSRAREAGINLSTTLNTALDAELRQHEMRKWKEENREAIDALNRFHEEHGCFSDEYRTF

Download         Length: 237 bp

>AT183157 NZ_CP086725:11119-11349 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4DW07

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4U7C9

References