Detailed information of TA system TA183148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 2361560..2361984
• Replicon: chromosome
• Accession: NZ_CP065670
• Organism: Sphingomonas paucimobilis strain FDAARGOS_908

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0C9M624
• Locus tag: I6G65_RS12805
• Protein ID: WP_007406919.1
• Coordinates: 2361560..2361835 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I6G65_RS12810
• Protein ID: WP_197913076.1
• Coordinates: 2361823..2361984 (-)
• Length: 54 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G65_RS12785	2357133..2357585	+	453	WP_007406920.1	large conductance mechanosensitive channel protein MscL	-
I6G65_RS12790	2357740..2358171	-	432	WP_007406932.1	Rrf2 family transcriptional regulator	-
I6G65_RS12800	2358962..2361532	-	2571	WP_007406927.1	DNA mismatch repair protein MutS	-
I6G65_RS12805	2361560..2361835	-	276	WP_007406919.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6G65_RS12810	2361823..2361984	-	162	WP_197913076.1	antitoxin	Antitoxin
I6G65_RS12815	2362135..2364393	+	2259	WP_007406925.1	NADP-dependent malic enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10372.73 Da
• Isoelectric Point: 5.5940

>T183148 WP_007406919.1 NZ_CP065670:c2361835-2361560 [Sphingomonas paucimobilis]
MAQISWSVQASLQLAAIVDYIEQFDPDAARRLGDRLIDVAESLRQFPDRGRPISHGRREMVTVRPYVLRYEHDGETVLIL
GIRHAAQLSDD

Nucleotide

• Length: 276 bp

>T183148 NZ_CP086724:810501-810911 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 54 a.a.
• Molecular weight: 6226.04 Da
• Isoelectric Point: 5.8087

>AT183148 WP_197913076.1 NZ_CP065670:c2361984-2361823 [Sphingomonas paucimobilis]
IFEQRDEAAELAADERARADFKAGRFVSHEKMAEWLKTWGTPDRKPLPPEWLK

Nucleotide

• Length: 162 bp

>AT183148 NZ_CP086724:810254-810520 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTATGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0C9M624