183144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5163646..5164325 Replicon chromosome
Accession NZ_CP065668
Organism Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6G66_RS24250 Protein ID WP_183021078.1
Coordinates 5163900..5164325 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6G66_RS24245 Protein ID WP_183021079.1
Coordinates 5163646..5163903 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G66_RS24220 5159384..5160178 - 795 WP_197954901.1 cobalt-precorrin-6A reductase -
I6G66_RS24225 5160177..5161379 + 1203 WP_183021086.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
I6G66_RS24230 5161376..5161873 + 498 WP_180318712.1 cobalamin biosynthesis protein -
I6G66_RS24235 5161870..5162736 + 867 WP_197954902.1 precorrin-4 C(11)-methyltransferase -
I6G66_RS24240 5162733..5163542 + 810 WP_197954903.1 precorrin-6A synthase (deacetylating) -
I6G66_RS24245 5163646..5163903 + 258 WP_183021079.1 plasmid stability protein stbC Antitoxin
I6G66_RS24250 5163900..5164325 + 426 WP_183021078.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G66_RS24255 5164364..5165413 - 1050 WP_183021077.1 NAD(P)-dependent alcohol dehydrogenase -
I6G66_RS24260 5165555..5166448 + 894 WP_183021076.1 LysR family transcriptional regulator -
I6G66_RS24265 5166606..5168027 + 1422 WP_183021075.1 chloride channel protein -
I6G66_RS24270 5168143..5168655 + 513 WP_012207634.1 MgtC/SapB family protein -
I6G66_RS24275 5168670..5169161 - 492 WP_183021074.1 type II toxin-antitoxin system YhaV family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15166.51 Da        Isoelectric Point: 6.2268

>T183144 WP_183021078.1 NZ_CP065668:5163900-5164325 [Delftia acidovorans]
MIVIDTNVISELWRLAPDARVLAWMDAQAIETLHLSAVTVAELRYGIAAMPEGRRRTIYQERLEHEVLPAFAGRVLAFDL
GAAKAYADLMASAKTQGKAIAKADGYIAATAMAHGLMVATRDTSPFEAGGLQTINPWTAAP

Download         Length: 426 bp

>T183144 NZ_CP086681:55561-55848 [Escherichia coli]
ATGACTTATACAGTAAAATTCCGGGATGATGCACTGAAAGAATGGCTCAGACTGGACAAGACCATTCAGCAGCAGTTCGC
AAAAAAACTGAAAAAATGCAGTGAAAATCCTCATATAGCTTCTGCAAAACTACGTGGATTAAAGGACTGCTATAAAATCA
AACTTCGCGCATCAGGTTTTCGTCTGGTTTATCAGGTTATTGATGATATGTTAATTATTGCGGTCGTCGCAGTAGGTAAA
CGTGAACGCAGCAACGTTTATCATCTCGCCAGTGAACGGATGAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9444.66 Da        Isoelectric Point: 6.7283

>AT183144 WP_183021079.1 NZ_CP065668:5163646-5163903 [Delftia acidovorans]
MANVTVRNLPDAVHRALRVRAAHHGRSTEAEIRDILEAAVRPAERVRLGSMLAAIAREAGGLTDSEAEEFNRLRDRTPAE
PMQFE

Download         Length: 258 bp

>AT183144 NZ_CP086681:55313-55564 [Escherichia coli]
ATGCCCAGTATCATTTTGTCTGACACCAGTGCAAGCGTCAGTGAGCTGAAAAAAAATCCGATGGCAACTGTCAGTGCCGG
AGAGGGGTATCCTGTTGCCATTCTTAACCGGAATCAGCCAGCATTCTACTGTGTCCCTGCTGAGCTCTATGAAAGAATGC
TTGATGCCTTGGATGACCAGGAGCTGGTAAAACTGGTTACTGAACGCAGCAGTCAGCCTCTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References