Detailed information of TA system TA183142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 3841686..3843369
• Replicon: chromosome
• Accession: NZ_CP065668
• Organism: Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: I6G66_RS18170
• Protein ID: WP_197953881.1
• Coordinates: 3842515..3843369 (-)
• Length: 285 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: I6G66_RS18165
• Protein ID: WP_183020658.1
• Coordinates: 3841686..3842492 (-)
• Length: 269 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G66_RS18135	3836756..3837640	-	885	WP_197953868.1	IclR family transcriptional regulator	-
I6G66_RS18140	3837653..3838423	-	771	WP_197953877.1	SDR family oxidoreductase	-
I6G66_RS18145	3839305..3839652	+	348	Protein_3507	type II toxin-antitoxin system RelE/ParE family toxin	-
I6G66_RS18150	3839649..3839957	+	309	WP_183020661.1	XRE family transcriptional regulator	-
I6G66_RS18155	3839982..3840731	-	750	WP_197953879.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-
I6G66_RS18160	3840834..3841631	-	798	WP_183020659.1	aspartate dehydrogenase	-
I6G66_RS18165	3841686..3842492	-	807	WP_183020658.1	IclR family transcriptional regulator	Antitoxin
I6G66_RS18170	3842515..3843369	-	855	WP_197953881.1	alpha/beta fold hydrolase	Toxin
I6G66_RS18175	3843519..3844049	-	531	WP_183020656.1	cupin domain-containing protein	-
I6G66_RS18180	3844233..3845429	-	1197	WP_197957478.1	MFS transporter	-
I6G66_RS18185	3845452..3846336	-	885	WP_197953882.1	NAD(P)-dependent oxidoreductase	-
I6G66_RS18190	3846473..3847063	-	591	WP_013804518.1	TetR/AcrR family transcriptional regulator	-
I6G66_RS18195	3847145..3847636	-	492	WP_016449824.1	Lrp/AsnC family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (44-277)

Antitoxin

• Transcription regulator IclR, C-terminal (137-255)

Sequences

Toxin

Protein

• Length: 285 a.a.
• Molecular weight: 29450.78 Da
• Isoelectric Point: 7.0199

>T183142 WP_197953881.1 NZ_CP065668:c3843369-3842515 [Delftia acidovorans]
MTPSVTACMEQRLQAQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALELAPRTRVLAWDAPGYGR
STPLAPAAPTGADYARVLAQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGCVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRRWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAQRLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Nucleotide

• Length: 855 bp

>T183142 NZ_CP086680:c33162-32881 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 269 a.a.
• Molecular weight: 29329.47 Da
• Isoelectric Point: 6.1163

>AT183142 WP_183020658.1 NZ_CP065668:c3842492-3841686 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRQLFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Nucleotide

• Length: 807 bp

>AT183142 NZ_CP086680:c33403-33152 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA