Detailed information of TA system TA183140

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3077657..3078288
• Replicon: chromosome
• Accession: NZ_CP065668
• Organism: Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6G66_RS14690
• Protein ID: WP_183020395.1
• Coordinates: 3077657..3078058 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A031HPK4
• Locus tag: I6G66_RS14695
• Protein ID: WP_043824440.1
• Coordinates: 3078055..3078288 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G66_RS14680	3072877..3077211	+	4335	WP_197957300.1	translocation/assembly module TamB domain-containing protein	-
I6G66_RS14690	3077657..3078058	-	402	WP_183020395.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G66_RS14695	3078055..3078288	-	234	WP_043824440.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I6G66_RS14700	3078365..3078625	+	261	Protein_2821	hypothetical protein	-
I6G66_RS14705	3078694..3079317	+	624	WP_197957301.1	glutathione transferase	-
I6G66_RS14710	3079339..3079563	+	225	WP_183020393.1	hypothetical protein	-
I6G66_RS14715	3079590..3080546	-	957	WP_197957461.1	tripartite tricarboxylate transporter substrate binding protein	-
I6G66_RS14720	3080649..3081587	-	939	WP_183020392.1	dihydrodipicolinate synthase family protein	-
I6G66_RS14725	3081680..3082492	+	813	WP_197957302.1	IclR family transcriptional regulator	-
I6G66_RS14730	3082515..3083048	-	534	WP_183020390.1	DUF2939 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-122)

Antitoxin

• SpoVT-AbrB domain (7-27)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14445.81 Da
• Isoelectric Point: 5.8323

>T183140 WP_183020395.1 NZ_CP065668:c3078058-3077657 [Delftia acidovorans]
MILLDTNICIYIINAKPPEVLARFQQYRMGEVGLCSVAAAELAFGVAKSGSARNRLALEMFLAPLTILPFDEAAVWAYGD
LRADLERRGSPIGALDTMIAAHALSQRALLVTNNTREFAKVPGLQLDNWAVAT

Nucleotide

• Length: 402 bp

>T183140 NZ_CP086679:c26639-25314 [Escherichia coli]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGAACGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8685.73 Da
• Isoelectric Point: 4.5183

>AT183140 WP_043824440.1 NZ_CP065668:c3078288-3078055 [Delftia acidovorans]
MDTARLFQSGRSQAVRLPKEYRFTGTEVVVKHFGNGVLLLPADDPWQTLQAGLAEFEPGFVLEREQPDAQQRDEISP

Nucleotide

• Length: 234 bp

>AT183140 NZ_CP086679:c26937-26644 [Escherichia coli]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A031HPK4