Detailed information of TA system TA183139

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT_toxin-BrnA
• Location: 2086705..2087248
• Replicon: chromosome
• Accession: NZ_CP065668
• Organism: Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: A0A7T2W0I6
• Locus tag: I6G66_RS10020
• Protein ID: WP_034368507.1
• Coordinates: 2086705..2086971 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: I6G66_RS10025
• Protein ID: WP_197956854.1
• Coordinates: 2086958..2087248 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G66_RS09995	2082057..2082422	+	366	WP_197956850.1	phage tail assembly protein	-
I6G66_RS10000	2082431..2082556	+	126	WP_096915334.1	GpE family phage tail protein	-
I6G66_RS10005	2082549..2085095	+	2547	WP_197956851.1	phage tail tape measure protein	-
I6G66_RS10010	2085108..2085572	+	465	WP_197956852.1	phage tail protein	-
I6G66_RS10015	2085572..2086651	+	1080	WP_197956853.1	phage late control D family protein	-
I6G66_RS10020	2086705..2086971	+	267	WP_034368507.1	BrnT family toxin	Toxin
I6G66_RS10025	2086958..2087248	+	291	WP_197956854.1	BrnA antitoxin family protein	Antitoxin
I6G66_RS10030	2087324..2087644	+	321	WP_197956855.1	hypothetical protein	-
I6G66_RS10035	2087641..2088516	+	876	WP_197956856.1	tyrosine-type recombinase/integrase	-
I6G66_RS10040	2088526..2088771	+	246	WP_197956857.1	hypothetical protein	-
I6G66_RS10045	2088815..2089024	+	210	WP_197956858.1	hypothetical protein	-
I6G66_RS10050	2089065..2089286	-	222	WP_197956859.1	hypothetical protein	-
I6G66_RS10055	2089270..2089653	-	384	WP_197956860.1	hypothetical protein	-
I6G66_RS10060	2089840..2090622	-	783	WP_197956861.1	WYL domain-containing protein	-
I6G66_RS10065	2090855..2091427	-	573	WP_197957440.1	helix-turn-helix domain-containing protein	-
I6G66_RS10070	2091509..2091775	+	267	WP_197956862.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2059436..2100996	41560

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-81)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (30-90)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10068.56 Da
• Isoelectric Point: 7.1648

>T183139 WP_034368507.1 NZ_CP065668:2086705-2086971 [Delftia acidovorans]
MDIEFDPAKNQANIDKHGVSLEMAGHIEWSNVLCMPDARRDYGEVREIGFTVIGQRLYVVVFVQRGQTMRIVSLRKANSR
EVKAYEAI

Nucleotide

• Length: 267 bp

>T183139 NZ_CP086678:4955290-4955397 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10425.13 Da
• Isoelectric Point: 10.0102

>AT183139 WP_197956854.1 NZ_CP065668:2086958-2087248 [Delftia acidovorans]
MKQSKKVGLIQPTAAEDAAIARGIEQDPDTMEITGDMLAEMQPLARRGRPPLEQPKLSMTMRVDADVLAAIKATGAGWQS
RVNEVLREAVKRGKLA

Nucleotide

• Length: 291 bp

>AT183139 NZ_CP086678:c4955240-4955177 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A7T2W0I6