Detailed information of TA system TA183138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1943904..1944943
• Replicon: chromosome
• Accession: NZ_CP065668
• Organism: Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: I6G66_RS09285
• Protein ID: WP_197956778.1
• Coordinates: 1943904..1944479 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: I6G66_RS09290
• Protein ID: WP_183018621.1
• Coordinates: 1944476..1944943 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G66_RS09265	1939601..1940149	-	549	WP_183018625.1	DUF2721 domain-containing protein	-
I6G66_RS09270	1940266..1941255	-	990	WP_197956776.1	LysR family transcriptional regulator	-
I6G66_RS09275	1941445..1942464	+	1020	WP_197956777.1	tripartite tricarboxylate transporter substrate binding protein BugE	-
I6G66_RS09280	1942461..1943888	+	1428	WP_183018622.1	amidohydrolase	-
I6G66_RS09285	1943904..1944479	-	576	WP_197956778.1	PIN domain-containing protein	Toxin
I6G66_RS09290	1944476..1944943	-	468	WP_183018621.1	helix-turn-helix domain-containing protein	Antitoxin
I6G66_RS09295	1945157..1945291	+	135	WP_016445252.1	DUF3149 domain-containing protein	-
I6G66_RS09300	1945347..1945604	-	258	WP_183018620.1	SlyX family protein	-
I6G66_RS09305	1945601..1946797	-	1197	WP_197956779.1	PLP-dependent aminotransferase family protein	-
I6G66_RS09310	1946936..1947922	-	987	WP_197956780.1	tripartite tricarboxylate transporter substrate binding protein	-
I6G66_RS09315	1947989..1949476	-	1488	WP_197956781.1	amidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (11-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-131)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21547.83 Da
• Isoelectric Point: 6.8358

>T183138 WP_197956778.1 NZ_CP065668:c1944479-1943904 [Delftia acidovorans]
MRHSPFTAIYDACVLYPAPLRDLLLWLGLSGLFRARWSAQIHDEWKRNLLLNRPDLHPEQLDRTCSLMDGAIPDALVTGH
EALVAGLSLPDPEDRHVLAAAIRCQAGVIVTFNLKDFPQASLQPFGIEAQHPDEFIANLFDLDRSAVLEAARRQRANLKR
PAMDAKHYLQVLRRQGLVQAEQLLGRFESII

Nucleotide

• Length: 576 bp

>T183138 NZ_CP086678:4954755-4954862 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17451.88 Da
• Isoelectric Point: 6.1401

>AT183138 WP_183018621.1 NZ_CP065668:c1944943-1944476 [Delftia acidovorans]
MSHAISSRVILPVEREVEAAVQSRRVLAAYVGTQRETQCIQIFDEHNQAHQVELPTSALRLLMDVLTELADGNAVQVVPI
HAELTTQEAADLLNVSRPHVVRLMEEGALPFHRAGKHRRVRFADLMQFKADRDNCSEQAMKELARQAQELGMGYE

Nucleotide

• Length: 468 bp

>AT183138 NZ_CP086678:c4954702-4954641 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT