Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 9059..9590 Replicon plasmid unnamed
Accession NZ_CP065667
Organism Delftia acidovorans strain FDAARGOS_909

Toxin (Protein)


Gene name relE Uniprot ID A0A7U1DYU7
Locus tag I6G66_RS00085 Protein ID WP_011798718.1
Coordinates 9309..9590 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag I6G66_RS00080 Protein ID WP_011114070.1
Coordinates 9059..9322 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G66_RS00035 4270..5034 - 765 WP_041836471.1 ParA family protein -
I6G66_RS00040 5031..5339 - 309 WP_041836477.1 transcriptional regulator KorA -
I6G66_RS00045 5446..5775 - 330 WP_011798723.1 DUF2761 domain-containing protein -
I6G66_RS00050 5778..6104 - 327 WP_011798722.1 hypothetical protein -
I6G66_RS00055 6313..6549 - 237 WP_011255200.1 stable inheritance protein KleA -
I6G66_RS00060 6706..6963 - 258 WP_011798721.1 hypothetical protein -
I6G66_RS00065 6980..8182 - 1203 WP_011798720.1 hypothetical protein -
I6G66_RS00070 8194..8457 - 264 WP_041836470.1 hypothetical protein -
I6G66_RS00075 8457..8888 - 432 WP_011304111.1 antirestriction protein -
I6G66_RS00080 9059..9322 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6G66_RS00085 9309..9590 + 282 WP_011798718.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6G66_RS00090 10652..12217 - 1566 Protein_17 Tn3-like element IS1071 family transposase -
I6G66_RS00095 12263..13276 - 1014 Protein_18 LacI family DNA-binding transcriptional regulator -
I6G66_RS00100 13273..14052 - 780 WP_197953180.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..73470 73470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10685.15 Da        Isoelectric Point: 8.1258

>T183137 WP_011798718.1 NZ_CP065667:9309-9590 [Delftia acidovorans]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALAGDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T183137 NZ_CP086678:c4649988-4649812 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT183137 WP_011114070.1 NZ_CP065667:9059-9322 [Delftia acidovorans]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT183137 NZ_CP086678:c4649766-4649350 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U1DYU7

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References