Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relE-dinJ/YafQ-RelB |
Location | 9059..9590 | Replicon | plasmid unnamed |
Accession | NZ_CP065667 | ||
Organism | Delftia acidovorans strain FDAARGOS_909 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A7U1DYU7 |
Locus tag | I6G66_RS00085 | Protein ID | WP_011798718.1 |
Coordinates | 9309..9590 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | dinJ | Uniprot ID | I2ALI8 |
Locus tag | I6G66_RS00080 | Protein ID | WP_011114070.1 |
Coordinates | 9059..9322 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6G66_RS00035 | 4270..5034 | - | 765 | WP_041836471.1 | ParA family protein | - |
I6G66_RS00040 | 5031..5339 | - | 309 | WP_041836477.1 | transcriptional regulator KorA | - |
I6G66_RS00045 | 5446..5775 | - | 330 | WP_011798723.1 | DUF2761 domain-containing protein | - |
I6G66_RS00050 | 5778..6104 | - | 327 | WP_011798722.1 | hypothetical protein | - |
I6G66_RS00055 | 6313..6549 | - | 237 | WP_011255200.1 | stable inheritance protein KleA | - |
I6G66_RS00060 | 6706..6963 | - | 258 | WP_011798721.1 | hypothetical protein | - |
I6G66_RS00065 | 6980..8182 | - | 1203 | WP_011798720.1 | hypothetical protein | - |
I6G66_RS00070 | 8194..8457 | - | 264 | WP_041836470.1 | hypothetical protein | - |
I6G66_RS00075 | 8457..8888 | - | 432 | WP_011304111.1 | antirestriction protein | - |
I6G66_RS00080 | 9059..9322 | + | 264 | WP_011114070.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
I6G66_RS00085 | 9309..9590 | + | 282 | WP_011798718.1 | type II toxin-antitoxin system YafQ family toxin | Toxin |
I6G66_RS00090 | 10652..12217 | - | 1566 | Protein_17 | Tn3-like element IS1071 family transposase | - |
I6G66_RS00095 | 12263..13276 | - | 1014 | Protein_18 | LacI family DNA-binding transcriptional regulator | - |
I6G66_RS00100 | 13273..14052 | - | 780 | WP_197953180.1 | SDR family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..73470 | 73470 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10685.15 Da Isoelectric Point: 8.1258
>T183137 WP_011798718.1 NZ_CP065667:9309-9590 [Delftia acidovorans]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALAGDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALAGDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL
Download Length: 282 bp
>T183137 NZ_CP086678:c4649988-4649812 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCGTGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9255.82 Da Isoelectric Point: 5.7905
>AT183137 WP_011114070.1 NZ_CP065667:9059-9322 [Delftia acidovorans]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD
Download Length: 264 bp
>AT183137 NZ_CP086678:c4649766-4649350 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U1DYU7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1U9V3I2 |