Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 347777..348426 Replicon chromosome
Accession NZ_CP065666
Organism Acinetobacter johnsonii strain FDAARGOS_910

Toxin (Protein)


Gene name cptA Uniprot ID A0A380U850
Locus tag I6G67_RS01835 Protein ID WP_004691280.1
Coordinates 348040..348426 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A380U7S7
Locus tag I6G67_RS01830 Protein ID WP_004691282.1
Coordinates 347777..348034 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G67_RS01810 343395..343760 + 366 WP_004691290.1 50S ribosomal protein L17 -
I6G67_RS01815 343956..345446 + 1491 WP_004691288.1 NAD(P)/FAD-dependent oxidoreductase -
I6G67_RS01820 345585..346376 + 792 WP_004691286.1 alpha/beta hydrolase -
I6G67_RS01825 346412..347584 - 1173 WP_004691284.1 acyl-CoA dehydrogenase family protein -
I6G67_RS01830 347777..348034 + 258 WP_004691282.1 succinate dehydrogenase assembly factor 2 Antitoxin
I6G67_RS01835 348040..348426 + 387 WP_004691280.1 hypothetical protein Toxin
I6G67_RS01840 349182..349424 + 243 WP_157786568.1 hypothetical protein -
I6G67_RS01845 349421..349984 + 564 WP_080593156.1 hypothetical protein -
I6G67_RS01850 350056..350628 + 573 WP_004691274.1 rhombosortase -
I6G67_RS01855 350811..353093 + 2283 WP_004691272.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(5-127)

Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 15322.27 Da        Isoelectric Point: 10.4419

>T183136 WP_004691280.1 NZ_CP065666:348040-348426 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPFGLWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNAQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Download         Length: 387 bp

>T183136 NZ_CP086678:4546040-4547362 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAATGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAACCGTTATGCCAGACCGTTATCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
TGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTGCCGGACGCAGAAATCATTAAAGCGGGGAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTATTGGGTGGCGCAGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGGTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTTCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGCCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10152.62 Da        Isoelectric Point: 4.7091

>AT183136 WP_004691282.1 NZ_CP065666:347777-348034 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADSAEKAMFAALVEQEDPDLLDWFMEVSEPPHPEMKTLIQKLK
HYVHG

Download         Length: 258 bp

>AT183136 NZ_CP086678:4545774-4546040 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGTCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TGACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380U850

Antitoxin

Source ID Structure
AlphaFold DB A0A380U7S7

References