Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) AbkB-brnA/BrnT-BrnA
Location 2601..3189 Replicon plasmid unnamed1
Accession NZ_CP065663
Organism Acinetobacter johnsonii strain FDAARGOS_910

Toxin (Protein)


Gene name AbkB Uniprot ID N9QW22
Locus tag I6G67_RS00020 Protein ID WP_005265091.1
Coordinates 2902..3189 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A376BDS1
Locus tag I6G67_RS00015 Protein ID WP_026056416.1
Coordinates 2601..2915 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G67_RS00010 1231..2499 - 1269 WP_115613865.1 hypothetical protein -
I6G67_RS00015 2601..2915 - 315 WP_026056416.1 BrnA antitoxin family protein Antitoxin
I6G67_RS00020 2902..3189 - 288 WP_005265091.1 BrnT family toxin Toxin
I6G67_RS00025 3420..4346 - 927 WP_005401983.1 LysR family transcriptional regulator -
I6G67_RS00030 4435..5073 + 639 WP_005401984.1 hypothetical protein -
I6G67_RS00035 5078..5710 + 633 WP_005401985.1 LysE family translocator -
I6G67_RS00040 5928..6251 - 324 WP_017397134.1 hypothetical protein -
I6G67_RS00045 6296..6871 - 576 WP_017397133.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..15161 15161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11262.66 Da        Isoelectric Point: 5.6205

>T183135 WP_005265091.1 NZ_CP065663:c3189-2902 [Acinetobacter johnsonii]
MEQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T183135 NZ_CP086678:4465068-4465355 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12249.89 Da        Isoelectric Point: 8.4842

>AT183135 WP_026056416.1 NZ_CP065663:c2915-2601 [Acinetobacter johnsonii]
MSMVRYSRKELNDKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWNNAVRHNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT183135 NZ_CP086678:4464829-4465068 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9QW22

Antitoxin

Source ID Structure
AlphaFold DB A0A376BDS1

References