Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 465051..465580 Replicon chromosome
Accession NZ_CP065656
Organism Staphylococcus epidermidis strain FDAARGOS_913

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6G70_RS02405 Protein ID WP_001829891.1
Coordinates 465218..465580 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6G70_RS02400 Protein ID WP_001829931.1
Coordinates 465051..465221 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G70_RS02375 460875..461354 + 480 WP_002457111.1 PH domain-containing protein -
I6G70_RS02380 461347..462852 + 1506 WP_002457110.1 PH domain-containing protein -
I6G70_RS02385 462839..463348 + 510 WP_002457109.1 PH domain-containing protein -
I6G70_RS02390 463396..463749 + 354 WP_002457108.1 holo-ACP synthase -
I6G70_RS02395 463816..464964 + 1149 WP_002457107.1 alanine racemase -
I6G70_RS02400 465051..465221 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6G70_RS02405 465218..465580 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6G70_RS02410 465925..466926 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6G70_RS02415 467026..467352 + 327 WP_001829952.1 anti-sigma factor antagonist -
I6G70_RS02420 467354..467833 + 480 WP_001829903.1 anti-sigma B factor RsbW -
I6G70_RS02425 467808..468578 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T183129 WP_001829891.1 NZ_CP065656:465218-465580 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T183129 NZ_CP086678:2979255-2979662 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT183129 WP_001829931.1 NZ_CP065656:465051-465221 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT183129 NZ_CP086678:2979008-2979274 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References