Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 453866..454375 Replicon chromosome
Accession NZ_CP065656
Organism Staphylococcus epidermidis strain FDAARGOS_913

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6G70_RS02345 Protein ID WP_001829980.1
Coordinates 454166..454375 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6G70_RS02340 Protein ID WP_001829893.1
Coordinates 453866..454159 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G70_RS02315 448874..449662 + 789 WP_002469583.1 hydroxyethylthiazole kinase -
I6G70_RS02320 449668..450306 + 639 WP_002505076.1 thiamine phosphate synthase -
I6G70_RS02325 450395..451267 + 873 WP_002470121.1 membrane protein insertase YidC -
I6G70_RS02330 451373..452026 - 654 WP_001829983.1 HD domain-containing protein -
I6G70_RS02335 452208..453692 - 1485 WP_002457116.1 cardiolipin synthase -
I6G70_RS02340 453866..454159 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6G70_RS02345 454166..454375 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6G70_RS02350 454518..454655 + 138 WP_001829949.1 hypothetical protein -
I6G70_RS02355 454754..455965 - 1212 WP_002486299.1 rod shape-determining protein RodA -
I6G70_RS02360 456356..457429 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
I6G70_RS02365 457441..458796 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T183128 WP_001829980.1 NZ_CP065656:454166-454375 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T183128 NZ_CP086678:c2698786-2698322 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAACCCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT183128 WP_001829893.1 NZ_CP065656:453866-454159 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT183128 NZ_CP086678:c2699121-2698786 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References