Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 6780907..6781949 | Replicon | chromosome |
| Accession | NZ_CP065652 | ||
| Organism | Achromobacter xylosoxidans strain FDAARGOS_915 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A0D6GAF2 |
| Locus tag | I6G72_RS31230 | Protein ID | WP_058207229.1 |
| Coordinates | 6781374..6781949 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A972JB12 |
| Locus tag | I6G72_RS31225 | Protein ID | WP_024067903.1 |
| Coordinates | 6780907..6781377 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6G72_RS31190 | 6776262..6777683 | - | 1422 | WP_024067909.1 | TIGR03752 family integrating conjugative element protein | - |
| I6G72_RS31195 | 6777673..6778611 | - | 939 | WP_024067908.1 | TIGR03749 family integrating conjugative element protein | - |
| I6G72_RS31200 | 6778608..6779306 | - | 699 | WP_024067907.1 | TIGR03746 family integrating conjugative element protein | - |
| I6G72_RS31205 | 6779303..6779701 | - | 399 | WP_058207559.1 | TIGR03750 family conjugal transfer protein | - |
| I6G72_RS31210 | 6779715..6780074 | - | 360 | WP_024067905.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| I6G72_RS31215 | 6780091..6780324 | - | 234 | WP_013520781.1 | TIGR03758 family integrating conjugative element protein | - |
| I6G72_RS31220 | 6780321..6780704 | - | 384 | WP_024067904.1 | RAQPRD family integrative conjugative element protein | - |
| I6G72_RS31225 | 6780907..6781377 | + | 471 | WP_024067903.1 | helix-turn-helix domain-containing protein | Antitoxin |
| I6G72_RS31230 | 6781374..6781949 | + | 576 | WP_058207229.1 | PIN domain-containing protein | Toxin |
| I6G72_RS31235 | 6781966..6782880 | + | 915 | WP_024067901.1 | AAA family ATPase | - |
| I6G72_RS31240 | 6782877..6783347 | + | 471 | WP_024067900.1 | hypothetical protein | - |
| I6G72_RS31245 | 6783344..6783844 | + | 501 | WP_024067899.1 | hypothetical protein | - |
| I6G72_RS31250 | 6783844..6784746 | + | 903 | WP_024067898.1 | nucleotidyltransferase domain-containing protein | - |
| I6G72_RS31255 | 6784783..6785508 | + | 726 | WP_024067897.1 | CBASS effector endonuclease NucC | - |
| I6G72_RS31260 | 6785550..6786452 | - | 903 | WP_024067896.1 | bacteriophage abortive infection AbiH family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 6721705..6810655 | 88950 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21576.73 Da Isoelectric Point: 5.2880
>T183127 WP_058207229.1 NZ_CP065652:6781374-6781949 [Achromobacter xylosoxidans]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLIKRPDLNRAQVDRTSDLMDRAIPDGVVEGY
EELVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNELLAAYGIEAQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDCFLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLIKRPDLNRAQVDRTSDLMDRAIPDGVVEGY
EELVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNELLAAYGIEAQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDCFLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T183127 NZ_CP086678:c1879054-1878743 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17225.63 Da Isoelectric Point: 6.3803
>AT183127 WP_024067903.1 NZ_CP065652:6780907-6781377 [Achromobacter xylosoxidans]
MTTTAAQSKMTLPAAAEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHLVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTTAAQSKMTLPAAAEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHLVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT183127 NZ_CP086678:c1878742-1878452 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|