Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 2504449..2505013 Replicon chromosome
Accession NZ_CP065652
Organism Achromobacter xylosoxidans strain FDAARGOS_915

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6IHV7
Locus tag I6G72_RS11720 Protein ID WP_020926667.1
Coordinates 2504732..2505013 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6IHW1
Locus tag I6G72_RS11715 Protein ID WP_020926666.1
Coordinates 2504449..2504745 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G72_RS11690 2499904..2500215 - 312 WP_006386651.1 helix-turn-helix domain-containing protein -
I6G72_RS11695 2500212..2500580 - 369 WP_006386650.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6G72_RS11700 2500750..2501685 - 936 WP_006386649.1 protein translocase subunit SecF -
I6G72_RS11705 2501737..2503617 - 1881 WP_006386648.1 protein translocase subunit SecD -
I6G72_RS11710 2503733..2504077 - 345 WP_006386647.1 preprotein translocase subunit YajC -
I6G72_RS11715 2504449..2504745 + 297 WP_020926666.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6G72_RS11720 2504732..2505013 + 282 WP_020926667.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G72_RS11725 2505063..2506199 - 1137 WP_024070175.1 tRNA guanosine(34) transglycosylase Tgt -
I6G72_RS11730 2506196..2507251 - 1056 WP_054442897.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -
I6G72_RS11735 2507487..2508320 - 834 WP_024070173.1 IclR family transcriptional regulator -
I6G72_RS11740 2508442..2509455 + 1014 WP_024070172.1 LLM class flavin-dependent oxidoreductase -
I6G72_RS11745 2509478..2509981 + 504 WP_006386642.1 flavin reductase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-52)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10262.77 Da        Isoelectric Point: 7.0080

>T183125 WP_020926667.1 NZ_CP065652:2504732-2505013 [Achromobacter xylosoxidans]
VPAVEWSSAARADLLAIVDYISDDNPDAAQRLKDDIETKAAQLPARPALYRPGRIAGTREMVVRANYIIVYAADALAVRI
LRILHAAQQWPPQ

Download         Length: 282 bp

>T183125 NZ_CP086678:c1557708-1557535 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10717.24 Da        Isoelectric Point: 7.3208

>AT183125 WP_020926666.1 NZ_CP065652:2504449-2504745 [Achromobacter xylosoxidans]
MPQTSMLHVRVDDKLKADATEKLAEFGLTISDAVRILLTRVAKEGGLPAGLTTDAQAHDAWFRAKVQEALADTGPAVPHQ
QVMDEAQALIDRKRRARS

Download         Length: 297 bp

>AT183125 NZ_CP086678:c1558032-1557736 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6IHV7

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6IHW1

References