Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1003297..1003851 Replicon chromosome
Accession NZ_CP065652
Organism Achromobacter xylosoxidans strain FDAARGOS_915

Toxin (Protein)


Gene name relE Uniprot ID A0A0D6FFH4
Locus tag I6G72_RS04695 Protein ID WP_006386989.1
Coordinates 1003297..1003575 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D6FFH2
Locus tag I6G72_RS04700 Protein ID WP_024067400.1
Coordinates 1003645..1003851 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G72_RS04670 999229..999915 + 687 WP_006386994.1 hypothetical protein -
I6G72_RS04675 1000000..1000476 - 477 WP_006386993.1 bacterioferritin -
I6G72_RS04680 1000901..1001815 - 915 WP_024067401.1 DMT family transporter -
I6G72_RS04685 1001929..1002849 + 921 WP_006386991.1 LysR family transcriptional regulator -
I6G72_RS04690 1002819..1003118 - 300 WP_006386990.1 (2Fe-2S)-binding protein -
I6G72_RS04695 1003297..1003575 - 279 WP_006386989.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G72_RS04700 1003645..1003851 - 207 WP_024067400.1 hypothetical protein Antitoxin
I6G72_RS04705 1003945..1005390 - 1446 WP_024067399.1 RNA polymerase factor sigma-54 -
I6G72_RS04710 1005389..1006039 + 651 WP_024067398.1 hypothetical protein -
I6G72_RS04715 1006232..1007209 + 978 WP_024067397.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10370.91 Da        Isoelectric Point: 9.0854

>T183124 WP_006386989.1 NZ_CP065652:c1003575-1003297 [Achromobacter xylosoxidans]
MLDVSWLQTAADDLAGIISYIAERSPQAARDLRQRIDNAVLSLARHPCRYRAGRVSGTRECVVHPNYVVVYRVTALAIEV
VNIVHARREYPP

Download         Length: 279 bp

>T183124 NZ_CP086678:c1458643-1458293 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7729.62 Da        Isoelectric Point: 4.5026

>AT183124 WP_024067400.1 NZ_CP065652:c1003851-1003645 [Achromobacter xylosoxidans]
MGPIPSSILSEFETEEQAVSYDRWFRAKVQASLDDPRPAVSHQRVMARIDAIIETACRRQLDPQDGEN

Download         Length: 207 bp

>AT183124 NZ_CP086678:c1458888-1458637 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6FFH4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D6FFH2

References