Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 82498..83071 Replicon chromosome
Accession NZ_CP065652
Organism Achromobacter xylosoxidans strain FDAARGOS_915

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6G72_RS00430 Protein ID WP_058207222.1
Coordinates 82498..82875 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6G72_RS00435 Protein ID WP_054471260.1
Coordinates 82862..83071 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G72_RS00405 79170..80087 + 918 WP_024067857.1 septum site-determining protein MinC -
I6G72_RS00410 80276..81091 + 816 WP_006388978.1 septum site-determining protein MinD -
I6G72_RS00415 81095..81352 + 258 WP_006388977.1 cell division topological specificity factor MinE -
I6G72_RS00420 81482..81706 - 225 WP_006388976.1 glycine zipper 2TM domain-containing protein -
I6G72_RS00425 81897..82430 - 534 WP_024067855.1 isochorismatase family protein -
I6G72_RS00430 82498..82875 - 378 WP_058207222.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G72_RS00435 82862..83071 - 210 WP_054471260.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6G72_RS00440 83196..84869 - 1674 WP_024067854.1 energy-dependent translational throttle protein EttA -
I6G72_RS00445 85021..85839 + 819 WP_058207221.1 AAC(3) family N-acetyltransferase -
I6G72_RS00450 85852..86778 - 927 WP_020924995.1 DMT family transporter -
I6G72_RS00455 86877..87665 + 789 WP_024067852.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13890.17 Da        Isoelectric Point: 6.3726

>T183123 WP_058207222.1 NZ_CP065652:c82875-82498 [Achromobacter xylosoxidans]
MILVDTSIWIDHLSDGEPCLVRLLEEESVLMHPFIAGELALGSLGRRDVVLGTMSLLPQVVRASHDEVMHFLHSERLFGK
GIGYVDLHLLASTRLTPGAALWTREKRLQALATTLSLAVDPPRYH

Download         Length: 378 bp

>T183123 NZ_CP086678:c1447042-1446752 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7521.62 Da        Isoelectric Point: 9.9435

>AT183123 WP_054471260.1 NZ_CP065652:c83071-82862 [Achromobacter xylosoxidans]
VRTTVTLDDDLLELARTYTGVQETSALVTRALTQLVQKEAAKRLAKLGGSSPKLKPIPRRQTETCNDPG

Download         Length: 210 bp

>AT183123 NZ_CP086678:c1447274-1447032 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References