Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4526615..4527251 Replicon chromosome
Accession NZ_CP065647
Organism Bacillus licheniformis strain FDAARGOS_923

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag I6G80_RS24235 Protein ID WP_003179128.1
Coordinates 4526615..4526965 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag I6G80_RS24240 Protein ID WP_006638778.1
Coordinates 4526970..4527251 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G80_RS24195 4521656..4522255 - 600 WP_003179145.1 SpoIIE family protein phosphatase -
I6G80_RS24200 4522252..4523043 - 792 WP_003179144.1 RNA polymerase sigma factor SigB -
I6G80_RS24205 4523009..4523494 - 486 WP_003179142.1 anti-sigma B factor RsbW -
I6G80_RS24210 4523494..4523820 - 327 WP_003179140.1 anti-sigma factor antagonist -
I6G80_RS24215 4523879..4524886 - 1008 WP_009330124.1 PP2C family protein-serine/threonine phosphatase -
I6G80_RS24220 4524897..4525298 - 402 WP_003179135.1 anti-sigma regulatory factor -
I6G80_RS24225 4525301..4525666 - 366 WP_003179132.1 STAS domain-containing protein -
I6G80_RS24230 4525670..4526497 - 828 WP_003179130.1 RsbT co-antagonist protein RsbRA -
I6G80_RS24235 4526615..4526965 - 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
I6G80_RS24240 4526970..4527251 - 282 WP_006638778.1 hypothetical protein Antitoxin
I6G80_RS24245 4527363..4528532 - 1170 WP_026080763.1 alanine racemase -
I6G80_RS24250 4528757..4529716 - 960 WP_152847888.1 outer membrane lipoprotein carrier protein LolA -
I6G80_RS24255 4530059..4530658 + 600 WP_003179118.1 rhomboid family intramembrane serine protease -
I6G80_RS24260 4530655..4532136 - 1482 WP_009330132.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T183120 WP_003179128.1 NZ_CP065647:c4526965-4526615 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

>T183120 NZ_CP086678:799921-800139 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT183120 WP_006638778.1 NZ_CP065647:c4527251-4526970 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp

>AT183120 NZ_CP086678:799521-799895 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References