Detailed information of TA system TA183118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 4821566..4822209
• Replicon: chromosome
• Accession: NZ_CP065640
• Organism: Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: I6G83_RS22710
• Protein ID: WP_054307159.1
• Coordinates: 4821793..4822209 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A4U9HL82
• Locus tag: I6G83_RS22705
• Protein ID: WP_054307160.1
• Coordinates: 4821566..4821796 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G83_RS22690	4817591..4819654	-	2064	WP_015673098.1	dimethylglycine demethylation protein DgcA	-
I6G83_RS22695	4819711..4820241	-	531	WP_054307162.1	4-vinyl reductase	-
I6G83_RS22700	4820273..4821250	-	978	WP_054307161.1	dipeptidase	-
I6G83_RS22705	4821566..4821796	+	231	WP_054307160.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
I6G83_RS22710	4821793..4822209	+	417	WP_054307159.1	type II toxin-antitoxin system VapC family toxin	Toxin
I6G83_RS22715	4822256..4823410	-	1155	WP_054307158.1	GlxA family transcriptional regulator	-
I6G83_RS22720	4823691..4825067	-	1377	WP_054307157.1	L-serine ammonia-lyase	-
I6G83_RS22725	4825355..4827010	+	1656	WP_054307156.1	BCCT family transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-129)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 14938.21 Da
• Isoelectric Point: 7.2920

>T183118 WP_054307159.1 NZ_CP065640:4821793-4822209 [Serratia rubidaea]
MSHTYMLDTCICSYIMREQPAAAIRRLEQAVMQRHRIVVSAITYAEMRFGAIGKKASPRHTQLVEAFCSRLDAILPWDRA
AVDETTTLKAALAAAGTPIGPNDTAIAGHAIATGAILVTNNDKEFARVPGLALEDWSA

Nucleotide

• Length: 417 bp

>T183118 NZ_CP086668:17676-18092 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8705.89 Da
• Isoelectric Point: 4.6182

>AT183118 WP_054307160.1 NZ_CP065640:4821566-4821796 [Serratia rubidaea]
MRTVSVFKNGNNRAIRLPRDMDFAGVNELEIVREGDTIILRPVKPSWGSFLLEDKADADFMTEREDIINDEGRVKP

Nucleotide

• Length: 231 bp

>AT183118 NZ_CP086668:17449-17679 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4U9HL82