Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4496536..4497209 Replicon chromosome
Accession NZ_CP065640
Organism Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)


Gene name vapC Uniprot ID L0MGK3
Locus tag I6G83_RS21180 Protein ID WP_015672838.1
Coordinates 4496536..4496976 (-) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4U9HLC0
Locus tag I6G83_RS21185 Protein ID WP_054307800.1
Coordinates 4496973..4497209 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G83_RS21160 4491811..4492674 - 864 WP_054307508.1 protein deglycase HchA -
I6G83_RS21165 4492813..4493214 - 402 WP_061322943.1 flagellar protein FlhE -
I6G83_RS21170 4493217..4495298 - 2082 WP_054307802.1 flagellar biosynthesis protein FlhA -
I6G83_RS21175 4495291..4496442 - 1152 WP_054307801.1 flagellar type III secretion system protein FlhB -
I6G83_RS21180 4496536..4496976 - 441 WP_015672838.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G83_RS21185 4496973..4497209 - 237 WP_054307800.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6G83_RS21190 4497339..4497983 - 645 WP_015672840.1 protein phosphatase CheZ -
I6G83_RS21195 4497996..4498385 - 390 WP_054307799.1 chemotaxis response regulator CheY -
I6G83_RS21200 4498483..4499532 - 1050 WP_054307798.1 chemotaxis response regulator protein-glutamate methylesterase -
I6G83_RS21205 4499532..4500392 - 861 WP_054307797.1 protein-glutamate O-methyltransferase CheR -
I6G83_RS21210 4500421..4502025 - 1605 WP_054307796.1 Tar ligand binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16276.71 Da        Isoelectric Point: 9.8304

>T183117 WP_015672838.1 NZ_CP065640:c4496976-4496536 [Serratia rubidaea]
MITHMLDTNIVIYVIKRRPREVLAVFNQHAGKMAISAVTYGELVHGVEKSARQVENLRVVEDFVSRLDVLPYTDKAAAHY
GNIRADLERKGTPIGVNDLHIAGHARSEGLVLVSNNLREFARIDGLRLENWLSSPIIPPSRPSSSK

Download         Length: 441 bp

>T183117 NZ_CP086667:56322-56804 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8827.72 Da        Isoelectric Point: 4.4013

>AT183117 WP_054307800.1 NZ_CP065640:c4497209-4496973 [Serratia rubidaea]
MTIGSVFTNNRSQAVRLPAEARFPDSVSKVTVRVVGKERVLAPVENTWDSFFDQESLSGDDFLNERAAQYQAERESFE

Download         Length: 237 bp

>AT183117 NZ_CP086667:56068-56334 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447QD36

Antitoxin

Source ID Structure
AlphaFold DB A0A4U9HLC0

References