Detailed information of TA system TA183108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3968392..3968917
• Replicon: chromosome
• Accession: NZ_CP065640
• Organism: Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: A0A4U9HI86
• Locus tag: I6G83_RS18610
• Protein ID: WP_054305388.1
• Coordinates: 3968392..3968697 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: A0A3S4GPB0
• Locus tag: I6G83_RS18615
• Protein ID: WP_054305389.1
• Coordinates: 3968699..3968917 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G83_RS18580	3963860..3965005	-	1146	WP_015672380.1	pyrroloquinoline quinone biosynthesis protein PqqE	-
I6G83_RS18585	3964998..3965276	-	279	WP_054305384.1	pyrroloquinoline quinone biosynthesis peptide chaperone PqqD	-
I6G83_RS18590	3965276..3966031	-	756	WP_054305385.1	pyrroloquinoline-quinone synthase PqqC	-
I6G83_RS18595	3966041..3966952	-	912	WP_054305386.1	pyrroloquinoline quinone biosynthesis protein PqqB	-
I6G83_RS18600	3967013..3967090	-	78	WP_004937827.1	pyrroloquinoline quinone precursor peptide PqqA	-
I6G83_RS18605	3967217..3968269	-	1053	WP_152972177.1	dipeptidase	-
I6G83_RS18610	3968392..3968697	-	306	WP_054305388.1	type II toxin-antitoxin system toxin CcdB	Toxin
I6G83_RS18615	3968699..3968917	-	219	WP_054305389.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
I6G83_RS18620	3969113..3971512	-	2400	WP_054305390.1	glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase	-
I6G83_RS18625	3972082..3972507	+	426	WP_015672386.1	hypothetical protein	-
I6G83_RS18630	3972521..3973822	+	1302	WP_054305391.1	sorbosone dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11654.32 Da
• Isoelectric Point: 4.2821

>T183108 WP_054305388.1 NZ_CP065640:c3968697-3968392 [Serratia rubidaea]
MQFRVYTYQRESRYSLFVDVQSDIIDTPGRRMVIPLVSARQLSDKVPYELYPLVQIANESYRLMTTEMASVPASVTGDEV
ADLSPWETEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T183108 NZ_CP086664:c4668529-4667996 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTTTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8545.53 Da
• Isoelectric Point: 5.1486

>AT183108 WP_054305389.1 NZ_CP065640:c3968917-3968699 [Serratia rubidaea]
MKQRITVTIDSDNYRVLKEADVNISGLVNRAMQNEARRLRAERWRAENREGMDEVARFIEMNGSFADENRDW

Nucleotide

• Length: 219 bp

>AT183108 NZ_CP086664:c4668806-4668540 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: A0A4U9HI86

Antitoxin

• AlphaFold DB: A0A3S4GPB0