Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2482396..2482931 Replicon chromosome
Accession NZ_CP065640
Organism Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)


Gene name relE Uniprot ID A0A4V6JGT0
Locus tag I6G83_RS11495 Protein ID WP_054305341.1
Coordinates 2482396..2482683 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3S4H852
Locus tag I6G83_RS11500 Protein ID WP_054305340.1
Coordinates 2482680..2482931 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G83_RS11480 2478022..2479767 - 1746 WP_054307426.1 aerobactin synthase IucA -
I6G83_RS11485 2479906..2481108 + 1203 WP_054307425.1 MFS transporter -
I6G83_RS11490 2481130..2482008 + 879 WP_054307424.1 siderophore-interacting protein -
I6G83_RS11495 2482396..2482683 - 288 WP_054305341.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G83_RS11500 2482680..2482931 - 252 WP_054305340.1 antitoxin Antitoxin
I6G83_RS11505 2483015..2483788 - 774 WP_054305339.1 amidohydrolase -
I6G83_RS11510 2483776..2484936 - 1161 WP_054305338.1 pyridoxal phosphate-dependent aminotransferase -
I6G83_RS11515 2485071..2485685 + 615 WP_054305337.1 methylthioribulose 1-phosphate dehydratase -
I6G83_RS11520 2485682..2486368 + 687 WP_054305336.1 acireductone synthase -
I6G83_RS11525 2486368..2486910 + 543 WP_015671079.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10946.02 Da        Isoelectric Point: 10.4726

>T183106 WP_054305341.1 NZ_CP065640:c2482683-2482396 [Serratia rubidaea]
MTYKVKFRESALKEWNRLDKALQQQFAKKLKKCCENPHIPAAKLRGMPGCYKIKLRASGFRLVYEVIDDCLVIAVVAVGK
RERGSVYQLSSERLK

Download         Length: 288 bp

>T183106 NZ_CP086664:c2675944-2674622 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCTATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9250.48 Da        Isoelectric Point: 3.9798

>AT183106 WP_054305340.1 NZ_CP065640:c2482931-2482680 [Serratia rubidaea]
VPNIILSDTSASISELKKNPMGTVNAGEGYPVAILNRNQPAFYCVPAALYEQMLDVLDEQELVRLVNERRNEALIDVDLD
QFT

Download         Length: 252 bp

>AT183106 NZ_CP086664:c2676210-2675944 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V6JGT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4H852

References