Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1190205..1190944 Replicon chromosome
Accession NZ_CP065640
Organism Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)


Gene name vapC Uniprot ID A0A4V6JIJ6
Locus tag I6G83_RS05575 Protein ID WP_054305752.1
Coordinates 1190465..1190944 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A4U9HX59
Locus tag I6G83_RS05570 Protein ID WP_054305753.1
Coordinates 1190205..1190468 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G83_RS05550 1186122..1186802 + 681 WP_015962207.1 GMP/IMP nucleotidase -
I6G83_RS05555 1186799..1187206 + 408 WP_054305077.1 ribosome-associated heat shock protein Hsp15 -
I6G83_RS05560 1187233..1188114 + 882 WP_054305076.1 Hsp33 family molecular chaperone HslO -
I6G83_RS05565 1188311..1189930 + 1620 WP_062779279.1 phosphoenolpyruvate carboxykinase (ATP) -
I6G83_RS05570 1190205..1190468 + 264 WP_054305753.1 hypothetical protein Antitoxin
I6G83_RS05575 1190465..1190944 + 480 WP_054305752.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G83_RS05580 1190978..1192351 - 1374 WP_015962213.1 two-component system sensor histidine kinase EnvZ -
I6G83_RS05585 1192348..1193067 - 720 WP_004709363.1 two-component system response regulator OmpR -
I6G83_RS05590 1193358..1193831 + 474 WP_015962214.1 transcription elongation factor GreB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17887.51 Da        Isoelectric Point: 4.9342

>T183105 WP_054305752.1 NZ_CP065640:1190465-1190944 [Serratia rubidaea]
MIILDTNVISETLRPKPHYNVISWLNEKDNSELYLSAIVVAELFSGIACMPDGKRQQALRLRLAEAIQINFDEQILPFDA
LCAMQYAELMGRNQRQGTPMSAPDAQIAATCLQYGATLATRNTKDFLHCGIELIDPWQVPAGQRLHEDAAEYYVMSRKS

Download         Length: 480 bp

>T183105 NZ_CP086664:1947299-1947401 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9862.27 Da        Isoelectric Point: 5.6211

>AT183105 WP_054305753.1 NZ_CP065640:1190205-1190468 [Serratia rubidaea]
MATITVRNLDDEVKELLRISAAKNGHSMEEEARMILKQALMKKPARYGLGSWMHQHFAEFGGVELAIPPRDVVPPRRVTF
DDDDDQA

Download         Length: 264 bp

>AT183105 NZ_CP086664:c1947408-1947263 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V6JIJ6

Antitoxin

Source ID Structure
AlphaFold DB A0A4U9HX59

References