Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 479833..480499 Replicon chromosome
Accession NZ_CP065640
Organism Serratia rubidaea strain FDAARGOS_926

Toxin (Protein)


Gene name cptA Uniprot ID A0A4V6JI41
Locus tag I6G83_RS02190 Protein ID WP_054306177.1
Coordinates 479833..480252 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S4X5M7
Locus tag I6G83_RS02195 Protein ID WP_054306178.1
Coordinates 480233..480499 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G83_RS02170 475805..477535 - 1731 WP_054306184.1 single-stranded-DNA-specific exonuclease RecJ -
I6G83_RS02175 477548..478264 - 717 WP_054306176.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6G83_RS02180 478292..479191 - 900 WP_015673665.1 site-specific tyrosine recombinase XerD -
I6G83_RS02185 479283..479801 + 519 WP_041411867.1 flavodoxin FldB -
I6G83_RS02190 479833..480252 - 420 WP_054306177.1 protein YgfX Toxin
I6G83_RS02195 480233..480499 - 267 WP_054306178.1 FAD assembly factor SdhE Antitoxin
I6G83_RS02200 480839..481831 + 993 WP_054306179.1 tRNA-modifying protein YgfZ -
I6G83_RS02205 481886..482566 - 681 WP_015673670.1 hemolysin III family protein -
I6G83_RS02210 482761..483369 + 609 WP_054306180.1 HD domain-containing protein -
I6G83_RS02215 483401..484720 - 1320 WP_054306181.1 MHS family MFS transporter -
I6G83_RS02220 484717..485370 - 654 WP_062779296.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16292.19 Da        Isoelectric Point: 11.2220

>T183104 WP_054306177.1 NZ_CP065640:c480252-479833 [Serratia rubidaea]
VAQWRCDVRISWRTQLVSLLAHGALILLILISPWPESYDPIWLLLLTLVVFECIRSQTRIASRQGELRLLSAPQRVIWQG
KEWRLARRPWMLRGGMLLTLQASGKRKRRRLWLASDCISSAEWRQLCQRMQLAEDESEG

Download         Length: 420 bp

>T183104 NZ_CP086664:817329-817739 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10361.79 Da        Isoelectric Point: 5.0718

>AT183104 WP_054306178.1 NZ_CP065640:c480499-480233 [Serratia rubidaea]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDDKALFVRLLQSDDPDLFNWLMNHGAPQDAELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT183104 NZ_CP086664:817082-817348 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V6JI41

Antitoxin

Source ID Structure
AlphaFold DB A0A3S4X5M7

References