Detailed information of TA system TA183103

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 71785..72410
• Replicon: plasmid unnamed
• Accession: NZ_CP065638
• Organism: Salmonella enterica strain FDAARGOS_928

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I6G85_RS00450
• Protein ID: WP_000911322.1
• Coordinates: 72012..72410 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: I6G85_RS00445
• Protein ID: WP_000450265.1
• Coordinates: 71785..72012 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G85_RS00445	71785..72012	+	228	WP_000450265.1	toxin-antitoxin system antitoxin VapB	Antitoxin
I6G85_RS00450	72012..72410	+	399	WP_000911322.1	tRNA(fMet)-specific endonuclease VapC	Toxin
I6G85_RS00455	72419..74662	-	2244	WP_000009320.1	type IV conjugative transfer system coupling protein TraD	-
I6G85_RS00460	75039..75770	-	732	WP_000782438.1	complement resistance protein TraT	-
I6G85_RS00465	75806..76300	-	495	WP_010999946.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..93933	93933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-87)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T183103 WP_000911322.1 NZ_CP065638:72012-72410 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T183103 NZ_CP086664:359001-359348 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT183103 WP_000450265.1 NZ_CP065638:71785-72012 [Salmonella enterica]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT183103 NZ_CP086664:359348-359647 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA