Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 44425..44950 Replicon plasmid unnamed
Accession NZ_CP065638
Organism Salmonella enterica strain FDAARGOS_928

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag I6G85_RS00295 Protein ID WP_001159863.1
Coordinates 44425..44730 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag I6G85_RS00300 Protein ID WP_000813641.1
Coordinates 44732..44950 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G85_RS00255 39804..40364 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
I6G85_RS00260 40520..40807 + 288 WP_071530243.1 hypothetical protein -
I6G85_RS00265 41084..41569 - 486 WP_000905606.1 membrane protein -
I6G85_RS00270 41563..42072 - 510 WP_001541544.1 CaiF/GrlA family transcriptional regulator -
I6G85_RS00275 42076..42789 - 714 Protein_54 EAL domain-containing protein -
I6G85_RS00280 42798..43580 - 783 WP_000082169.1 site-specific integrase -
I6G85_RS00285 43615..44136 - 522 WP_000198608.1 hypothetical protein -
I6G85_RS00290 44133..44423 - 291 WP_001266176.1 hypothetical protein -
I6G85_RS00295 44425..44730 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
I6G85_RS00300 44732..44950 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
I6G85_RS00305 45626..46147 + 522 WP_010999942.1 hypothetical protein -
I6G85_RS00310 46631..46927 + 297 WP_001687482.1 hypothetical protein -
I6G85_RS00315 47421..48410 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
I6G85_RS00320 48669..49113 - 445 Protein_63 site-specific integrase -
I6G85_RS00325 49282..49663 - 382 Protein_64 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..93933 93933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(23-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T183102 WP_001159863.1 NZ_CP065638:c44730-44425 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T183102 NZ_CP086664:333032-333400 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGTCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTATAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT183102 WP_000813641.1 NZ_CP065638:c44950-44732 [Salmonella enterica]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT183102 NZ_CP086664:332814-333035 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGCTCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References