183100

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 611018..611539 Replicon chromosome
Accession NZ_CP065635
Organism Staphylococcus pseudintermedius strain FDAARGOS_930

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag I6G87_RS03155 Protein ID WP_014613364.1
Coordinates 611018..611239 (-) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag I6G87_RS03160 Protein ID WP_014613363.1
Coordinates 611252..611539 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G87_RS03140 608295..608441 - 147 WP_014613367.1 hypothetical protein -
I6G87_RS03145 608527..610707 - 2181 WP_037542539.1 heavy metal translocating P-type ATPase -
I6G87_RS03150 610808..611014 - 207 WP_014613365.1 cation transporter -
I6G87_RS03155 611018..611239 - 222 WP_014613364.1 heavy-metal-associated domain-containing protein Toxin
I6G87_RS03160 611252..611539 - 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6G87_RS03165 611671..613161 + 1491 WP_014613362.1 cardiolipin synthase -
I6G87_RS03170 613182..613838 + 657 WP_014613361.1 HD domain-containing protein -
I6G87_RS03175 613892..614758 - 867 WP_014613360.1 membrane protein insertase YidC -
I6G87_RS03180 614847..615485 - 639 WP_014613359.1 thiamine phosphate synthase -
I6G87_RS03185 615475..616278 - 804 WP_014613358.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T183100 WP_014613364.1 NZ_CP065635:c611239-611018 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

>T183100 NZ_CP086662:4359489-4359791 [Escherichia coli]
ATGGCTCAAAAGAATAATATAAGGAGTTTTCGTGATGCCTGGCTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCTCGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTGTCCGGGAAATTACAGGAATATTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATATTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT183100 WP_014613363.1 NZ_CP065635:c611539-611252 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT183100 NZ_CP086662:4359827-4360168 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References