183099

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 594765..595289 Replicon chromosome
Accession NZ_CP065635
Organism Staphylococcus pseudintermedius strain FDAARGOS_930

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag I6G87_RS03075 Protein ID WP_014613379.1
Coordinates 594765..595118 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag I6G87_RS03080 Protein ID WP_014613378.1
Coordinates 595119..595289 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G87_RS03055 592074..592844 - 771 WP_015729428.1 RNA polymerase sigma factor SigB -
I6G87_RS03060 592819..593298 - 480 WP_031253870.1 anti-sigma B factor RsbW -
I6G87_RS03065 593298..593624 - 327 WP_014613381.1 anti-sigma factor antagonist -
I6G87_RS03070 593703..594707 - 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
I6G87_RS03075 594765..595118 - 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6G87_RS03080 595119..595289 - 171 WP_014613378.1 hypothetical protein Antitoxin
I6G87_RS03085 595374..596522 - 1149 WP_014613377.1 alanine racemase -
I6G87_RS03090 596556..596906 - 351 WP_037542556.1 holo-ACP synthase -
I6G87_RS03095 596903..597421 - 519 WP_014613375.1 PH domain-containing protein -
I6G87_RS03100 597405..598934 - 1530 WP_037542554.1 PH domain-containing protein -
I6G87_RS03105 598927..599400 - 474 WP_037542551.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T183099 WP_014613379.1 NZ_CP065635:c595118-594765 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T183099 NZ_CP086662:c4331634-4331416 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT183099 WP_014613378.1 NZ_CP065635:c595289-595119 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT183099 NZ_CP086662:c4332034-4331660 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References