Detailed information of TA system TA183098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 61265..61830
• Replicon: chromosome
• Accession: NZ_CP065631
• Organism: Fannyhessea vaginae strain FDAARGOS_934

Toxin (Protein)

• Gene name: relE
• Uniprot ID: F1T6X0
• Locus tag: I6G91_RS00260
• Protein ID: WP_006303416.1
• Coordinates: 61265..61543 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F1T6W9
• Locus tag: I6G91_RS00265
• Protein ID: WP_006303415.1
• Coordinates: 61549..61830 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6G91_RS00235	57118..57336	+	219	WP_006303421.1	helix-turn-helix domain-containing protein	-
I6G91_RS00240	57333..57752	+	420	WP_006303420.1	hypothetical protein	-
I6G91_RS00245	58250..59236	+	987	WP_006303419.1	helix-turn-helix domain-containing protein	-
I6G91_RS00250	59340..60548	+	1209	WP_006303418.1	ATP-binding protein	-
I6G91_RS00255	60662..61168	+	507	WP_006303417.1	GNAT family N-acetyltransferase	-
I6G91_RS00260	61265..61543	-	279	WP_006303416.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I6G91_RS00265	61549..61830	-	282	WP_006303415.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6G91_RS00270	62167..63231	+	1065	WP_006303414.1	LacI family transcriptional regulator	-
I6G91_RS00275	63509..65977	+	2469	WP_006303412.1	phosphoketolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10614.26 Da
• Isoelectric Point: 7.9270

>T183098 WP_006303416.1 NZ_CP065631:c61543-61265 [Fannyhessea vaginae]
MLKLQATSKFRKDYKRIKKRGLDISSLQEVLDKLCAGETLDLKHKDHALTGSYQGFRECHIQPDWLLIYAIHEDELILVA
SRTGSHADLFNM

Nucleotide

• Length: 279 bp

>T183098 NZ_CP086662:c4083520-4083242 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10221.66 Da
• Isoelectric Point: 4.5556

>AT183098 WP_006303415.1 NZ_CP065631:c61830-61549 [Fannyhessea vaginae]
MATSPTQIRIDSTVKKDANELFSELGIDMSSAVNIFLRQCILRGGLPFKVEVPKYNAETLAAMQEARDIISGKIQATSYN
TTDELLKALNAED

Nucleotide

• Length: 282 bp

>AT183098 NZ_CP086662:c4083783-4083523 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: F1T6X0

Antitoxin

• AlphaFold DB: F1T6W9