Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2943594..2944225 Replicon chromosome
Accession NZ_CP065627
Organism Delftia acidovorans strain FDAARGOS_939

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6G96_RS13275 Protein ID WP_180318010.1
Coordinates 2943824..2944225 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6G96_RS13270 Protein ID WP_180318011.1
Coordinates 2943594..2943827 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G96_RS13245 2940566..2941099 + 534 WP_046987310.1 DUF2939 domain-containing protein -
I6G96_RS13250 2941133..2941357 - 225 WP_016453212.1 hypothetical protein -
I6G96_RS13255 2941379..2942002 - 624 WP_097203438.1 glutathione transferase -
I6G96_RS13260 2942082..2942762 - 681 WP_141830100.1 hypothetical protein -
I6G96_RS13265 2942895..2943437 + 543 WP_197945067.1 helix-turn-helix domain-containing protein -
I6G96_RS13270 2943594..2943827 + 234 WP_180318011.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6G96_RS13275 2943824..2944225 + 402 WP_180318010.1 type II toxin-antitoxin system VapC family toxin Toxin
I6G96_RS13280 2944489..2945301 + 813 Protein_2617 phage portal protein -
I6G96_RS13285 2945520..2946443 - 924 WP_197945068.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(7-27)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14458.81 Da        Isoelectric Point: 5.8323

>T183094 WP_180318010.1 NZ_CP065627:2943824-2944225 [Delftia acidovorans]
MILLDTNICIYIINAKPPEVLARFQQYRMGEVGLCSVVAAELAFGVAKSGSARNRQALEMFLAPLAILPFDEAAVWAYGD
LRADLERRGSPIGALDTMIAAHALSQRALLVTNNTREFAKVPGLQLDNWAVAT

Download         Length: 402 bp

>T183094 NZ_CP086662:3186937-3187248 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8699.76 Da        Isoelectric Point: 4.5338

>AT183094 WP_180318011.1 NZ_CP065627:2943594-2943827 [Delftia acidovorans]
MDTARLFQSGRSQAVRLPKEYRFTGTEVVVKHFGNGVLLLPADDPWQTLQAGLAEFEPGFVLEREQPEAQQRDEISP

Download         Length: 234 bp

>AT183094 NZ_CP086662:3187249-3187539 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References