Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2220164..2221847 Replicon chromosome
Accession NZ_CP065627
Organism Delftia acidovorans strain FDAARGOS_939

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag I6G96_RS10000 Protein ID WP_197944797.1
Coordinates 2220164..2221018 (+) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag I6G96_RS10005 Protein ID WP_012202883.1
Coordinates 2221041..2221847 (+) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G96_RS09975 2215898..2216389 + 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -
I6G96_RS09980 2216471..2217061 + 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
I6G96_RS09985 2217198..2218082 + 885 WP_197944796.1 NAD(P)-dependent oxidoreductase -
I6G96_RS09990 2218105..2219301 + 1197 WP_197945202.1 MFS transporter -
I6G96_RS09995 2219484..2220014 + 531 WP_012202881.1 cupin domain-containing protein -
I6G96_RS10000 2220164..2221018 + 855 WP_197944797.1 alpha/beta fold hydrolase Toxin
I6G96_RS10005 2221041..2221847 + 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
I6G96_RS10010 2221902..2222699 + 798 WP_197944798.1 aspartate dehydrogenase -
I6G96_RS10015 2222811..2223572 + 762 WP_197944799.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
I6G96_RS10020 2223585..2223893 - 309 WP_013804512.1 XRE family transcriptional regulator -
I6G96_RS10025 2223890..2224237 - 348 WP_071954163.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6G96_RS10030 2224556..2224837 - 282 WP_071954164.1 hypothetical protein -
I6G96_RS10035 2225670..2226440 + 771 WP_197944800.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29522.89 Da        Isoelectric Point: 7.0300

>T183092 WP_197944797.1 NZ_CP065627:2220164-2221018 [Delftia acidovorans]
MTPSVTACMEQRLQAQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALALAPRTRVLAWEAPGYGR
STPLAPAVPTGADYARMLEQSLQALGVRRCLLVGHSLGALMGTPWAVQTGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T183092 NZ_CP086662:c2802312-2802205 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAATAA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT183092 WP_012202883.1 NZ_CP065627:2221041-2221847 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp

>AT183092 NZ_CP086662:2802369-2802424 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References