Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3673316..3674070 | Replicon | chromosome |
| Accession | NZ_CP065626 | ||
| Organism | Edwardsiella hoshinae strain FDAARGOS_940 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A377E3D6 |
| Locus tag | I6G97_RS17195 | Protein ID | WP_001194695.1 |
| Coordinates | 3673693..3674070 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | I6G97_RS17190 | Protein ID | WP_165688905.1 |
| Coordinates | 3673316..3673642 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6G97_RS17145 | 3668522..3668974 | + | 453 | WP_024523877.1 | hypothetical protein | - |
| I6G97_RS17150 | 3668971..3669423 | + | 453 | WP_000734138.1 | hypothetical protein | - |
| I6G97_RS17155 | 3669486..3670028 | + | 543 | WP_001104018.1 | DUF4339 domain-containing protein | - |
| I6G97_RS17160 | 3670088..3670540 | + | 453 | WP_020837115.1 | hypothetical protein | - |
| I6G97_RS17165 | 3670617..3670850 | + | 234 | WP_024523878.1 | DUF905 domain-containing protein | - |
| I6G97_RS17170 | 3670970..3671788 | + | 819 | WP_001234406.1 | DUF945 domain-containing protein | - |
| I6G97_RS17175 | 3672056..3672526 | + | 471 | WP_024523879.1 | antirestriction protein | - |
| I6G97_RS17180 | 3672538..3673017 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| I6G97_RS17185 | 3673038..3673259 | + | 222 | WP_000691981.1 | DUF987 domain-containing protein | - |
| I6G97_RS17190 | 3673316..3673642 | + | 327 | WP_165688905.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| I6G97_RS17195 | 3673693..3674070 | + | 378 | WP_001194695.1 | TA system toxin CbtA family protein | Toxin |
| I6G97_RS17200 | 3674067..3674558 | + | 492 | WP_000777682.1 | hypothetical protein | - |
| I6G97_RS17205 | 3674590..3674793 | + | 204 | WP_000413747.1 | DUF957 domain-containing protein | - |
| I6G97_RS17210 | 3674874..3675718 | + | 845 | Protein_3258 | DUF4942 domain-containing protein | - |
| I6G97_RS17220 | 3676061..3676792 | - | 732 | WP_024523880.1 | DNA polymerase III subunit epsilon | - |
| I6G97_RS17225 | 3676860..3677330 | + | 471 | WP_024523881.1 | ribonuclease HI | - |
| I6G97_RS17230 | 3677327..3678049 | - | 723 | WP_024523882.1 | methyltransferase domain-containing protein | - |
| I6G97_RS17235 | 3678081..3678836 | + | 756 | WP_024523883.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3649091..3678836 | 29745 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14180.97 Da Isoelectric Point: 7.4209
>T183089 WP_001194695.1 NZ_CP065626:3673693-3674070 [Edwardsiella hoshinae]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKATGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T183089 NZ_CP086662:2395033-2395497 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11889.62 Da Isoelectric Point: 6.9453
>AT183089 WP_165688905.1 NZ_CP065626:3673316-3673642 [Edwardsiella hoshinae]
ITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELTPRHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
ITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELTPRHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 327 bp
>AT183089 NZ_CP086662:2394698-2395033 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|