Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1770717..1771309 Replicon chromosome
Accession NZ_CP065626
Organism Edwardsiella hoshinae strain FDAARGOS_940

Toxin (Protein)


Gene name Hha Uniprot ID A0A376DIY5
Locus tag I6G97_RS08295 Protein ID WP_024523032.1
Coordinates 1770717..1770920 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A376DJI4
Locus tag I6G97_RS08300 Protein ID WP_024523031.1
Coordinates 1770941..1771309 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G97_RS08265 1766288..1766749 + 462 WP_024523037.1 Lrp/AsnC family transcriptional regulator -
I6G97_RS08270 1767028..1767366 + 339 WP_024523036.1 P-II family nitrogen regulator -
I6G97_RS08275 1767393..1768670 + 1278 WP_024523035.1 ammonium transporter AmtB -
I6G97_RS08280 1768695..1769561 - 867 WP_024523034.1 acyl-CoA thioesterase II -
I6G97_RS08285 1769642..1769971 - 330 WP_024523033.1 MGMT family protein -
I6G97_RS08295 1770717..1770920 - 204 WP_024523032.1 hemolysin expression modulator Hha Toxin
I6G97_RS08300 1770941..1771309 - 369 WP_024523031.1 Hha toxicity modulator TomB Antitoxin
I6G97_RS08305 1771680..1774835 - 3156 WP_024523030.1 multidrug efflux RND transporter permease subunit -
I6G97_RS08310 1774880..1776064 - 1185 WP_024523029.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8102.39 Da        Isoelectric Point: 5.8288

>T183080 WP_024523032.1 NZ_CP065626:c1770920-1770717 [Edwardsiella hoshinae]
MTKIDYLMKLRKCTSLETLERVIEKNKYELSNDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T183080 NZ_CP065626:c1770920-1770717 [Edwardsiella hoshinae]
ATGACCAAAATCGACTATCTGATGAAGTTGCGTAAGTGCACGTCGCTGGAGACGCTGGAACGCGTGATCGAAAAGAATAA
ATATGAGCTTTCCAATGATGAGCTAGAAATTTTTTATTCCGCTGCCGATCATCGCTTAGCCGAATTAACTATGAATAAGC
TATACGATAAAATTCCGGCCGAAGTCTGGCAATATGTACGCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14255.03 Da        Isoelectric Point: 5.9979

>AT183080 WP_024523031.1 NZ_CP065626:c1771309-1770941 [Edwardsiella hoshinae]
MDEYTSYRHDIAELKYLCDSLYHQGMDVLEESHHGWVSDPTAMVNLQLNELIEHIANVALSFKIKYPQHSSLCEIVDDYL
DETYALFSAYSISEQALRHWLRSKRRVAYSLAHEKRNAALHV

Download         Length: 369 bp

>AT183080 NZ_CP065626:c1771309-1770941 [Edwardsiella hoshinae]
ATGGATGAGTACACATCTTATCGACATGACATCGCAGAGCTGAAATATCTGTGTGATTCTCTGTATCATCAGGGAATGGA
TGTCCTGGAAGAGAGCCATCATGGCTGGGTCAGCGATCCGACGGCAATGGTTAATCTTCAGCTCAACGAGTTGATTGAAC
ATATTGCCAACGTAGCGTTGTCATTTAAGATTAAATATCCACAGCATTCGTCCCTTTGCGAAATAGTGGATGATTATCTG
GATGAAACCTATGCCTTGTTCAGCGCCTATAGCATCAGTGAGCAGGCGCTCAGGCACTGGTTACGAAGCAAACGCAGGGT
AGCGTACTCGCTAGCACATGAAAAGCGTAACGCCGCCTTGCATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376DIY5

Antitoxin

Source ID Structure
AlphaFold DB A0A376DJI4

References