Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 108911..109580 Replicon chromosome
Accession NZ_CP065626
Organism Edwardsiella hoshinae strain FDAARGOS_940

Toxin (Protein)


Gene name cptA Uniprot ID A0A376D7Q3
Locus tag I6G97_RS00830 Protein ID WP_024524368.1
Coordinates 108911..109333 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A376D8K0
Locus tag I6G97_RS00835 Protein ID WP_024524369.1
Coordinates 109314..109580 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G97_RS00810 104775..106508 - 1734 WP_024524364.1 single-stranded-DNA-specific exonuclease RecJ -
I6G97_RS00815 106513..107229 - 717 WP_024524365.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6G97_RS00820 107257..108156 - 900 WP_024524366.1 site-specific tyrosine recombinase XerD -
I6G97_RS00825 108302..108820 + 519 WP_024524367.1 flavodoxin FldB -
I6G97_RS00830 108911..109333 - 423 WP_024524368.1 protein YgfX Toxin
I6G97_RS00835 109314..109580 - 267 WP_024524369.1 FAD assembly factor SdhE Antitoxin
I6G97_RS00840 109981..110976 + 996 WP_024524370.1 tRNA-modifying protein YgfZ -
I6G97_RS00845 111028..111852 - 825 WP_024524371.1 shikimate 5-dehydrogenase -
I6G97_RS00850 112080..112955 - 876 WP_024524372.1 nucleoside-specific channel-forming protein Tsx -
I6G97_RS00855 113529..114179 + 651 WP_024524373.1 hemolysin III family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-135)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16237.92 Da        Isoelectric Point: 9.8771

>T183078 WP_024524368.1 NZ_CP065626:c109333-108911 [Edwardsiella hoshinae]
VAPWCCNIHVSWRTQVIALLGYGALVLAILLAPWPESYGVSAIWLVLLVAVIFECIRSQRRIARNRGELQYHATGEWRWQ
QREWRLARRPWISDMGVLLLLQSCTGPARRRRLWLAADSMSRDEWSELRALLLNTRGADD

Download         Length: 423 bp

>T183078 NZ_CP086659:2106106-2106291 [Staphylococcus capitis]
GTGAGTTTGCATTTTCAAATATTGTTATGGCTAGCAATTATATTTATTGTCGCTGGAGCTATTATTTTAACAATTATGCT
TAAGACTAAGAAAGAAGAAAGAAAAGAATCTTATTTAGGATTTACTGTAATATTCTTGATTTTTGGATTTGCTATGCTTA
TATACACACTCATTTTCGGATTGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10445.11 Da        Isoelectric Point: 5.6981

>AT183078 WP_024524369.1 NZ_CP065626:c109580-109314 [Edwardsiella hoshinae]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYETMSDADKQTFVRLLSYDDPELFKWLMNQGVPEDVELARMITLIQTRN
KARGPMVL

Download         Length: 267 bp

>AT183078 NZ_CP086659:2105816-2106073 [Staphylococcus capitis]
ATGAAAATATTTAGTATAAATGTGATTAATATTTTATTGACCATATTATTTATAGCCTTTAATGTGCTTATAACTTATAA
CGCAAATGTTGATAATCAATTATGGTTGATACCAGGATTATGTATTTGTGGCGTCGCTTTATTCACTAGTCTAATAATAG
CTATTATTTACACTGATTTGCTAAGCGAAATTATATTTTTCATAAATATAGTATTAGCACTTTACTATATTTATCCTATT
TTTTACGACTTCTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376D7Q3

Antitoxin

Source ID Structure
AlphaFold DB A0A376D8K0

References