Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 16122..16666 Replicon plasmid unnamed
Accession NZ_CP065625
Organism Edwardsiella hoshinae strain FDAARGOS_940

Toxin (Protein)


Gene name relE Uniprot ID A0A376IXW9
Locus tag I6G97_RS00070 Protein ID WP_071991035.1
Coordinates 16391..16666 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A376IZ90
Locus tag I6G97_RS00065 Protein ID WP_024524788.1
Coordinates 16122..16391 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G97_RS00055 14487..15212 + 726 WP_024524786.1 type-F conjugative transfer system pilin acetylase TraX -
I6G97_RS00060 15227..15847 + 621 WP_024524787.1 fertility inhibition protein FinO -
I6G97_RS00065 16122..16391 + 270 WP_024524788.1 ribbon-helix-helix domain-containing protein Antitoxin
I6G97_RS00070 16391..16666 + 276 WP_071991035.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6G97_RS00075 16961..17035 + 75 WP_071991036.1 RepA leader peptide Tap -
I6G97_RS00080 17172..18107 + 936 WP_024524789.1 replication protein -
I6G97_RS00085 19080..20027 + 948 WP_115314659.1 Rpn family recombination-promoting nuclease/putative transposase -
I6G97_RS00090 20205..20857 - 653 Protein_17 IS1 family transposase -
I6G97_RS00095 21051..21497 + 447 WP_024525000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..57741 57741


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-46)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10719.43 Da        Isoelectric Point: 9.4767

>T183077 WP_071991035.1 NZ_CP065625:16391-16666 [Edwardsiella hoshinae]
MELKWTSKALSDLARLYEFLACSNKISAARAVQSLAQYPMTLLTNPRIGEQLFQFEPREVRRILVGGYEIRYEILDSGIY
ILRLWHTRENR

Download         Length: 276 bp

>T183077 NZ_CP086659:1108368-1108547 [Staphylococcus capitis]
ATGAATAAAGAATATGAATCTAAATTGAATTATCATGAAGAAGAAAATGCTATGGTTACAGATTTAGATGATTTAAAAGA
ATTAGGAAAAGAAATGGAACAAATTTCAGAAGAAAATGATGAAGATAAATTAAACCAATCTCATGATGAAGATGTTCATT
CTGACCTTAATAATGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9787.23 Da        Isoelectric Point: 6.4602

>AT183077 WP_024524788.1 NZ_CP065625:16122-16391 [Edwardsiella hoshinae]
MTQATTRVLTAHVPLPMADKVDQIAARLERSRGWVMKQALSAWIAQEEARDRLTQEALADVGAGRVIDHLAVLAWADSLS
SDQPMPVPR

Download         Length: 270 bp

>AT183077 NZ_CP086659:1107741-1108340 [Staphylococcus capitis]
ATGGCAATGAACTTTAAAGTATTTGAAAATAGTGAAAGAGTAGCAGAATATGCTGCAGATATTATTCGTAAACAATTTAA
TAATAATCCAACTACAATTGCAGGTTTTCACTTAGAAAAAGATCACGCACCTGTATTAGATGAACTTAAGAAAAATGTAG
ATACGCATGCTTTAGATTTCAGCCAAATCAATATTTTAGATTATGATGATAATAGATCTTATTATGAAGCATTAGGTGTA
CCTGAAAGCCAAGTGTATTCAATTTCTTACGAACAAGATGCAATTGATTTTATTTCAGATAAAATGAAAACTAAAGAAAA
TAAAGGTAAATTAATCCTTCAAGTTCTTTCAATTGATGAAAGTGGCAAGTTAGATGTAAGTGTACGTCAAGGCCTTATGG
AAGCTAGAGAAATTTTCTTAGTTGTTACAGGTAGTAATAAACGTGAAGTTATTGAAAAACTTTATCGTGAAAACGGCAAA
TCTAGTTATGAGCCAGCAGATCTTAAAGCACACCGCATGGTAAATGTTATTTTAGATAAAGAAGCGGCTGCAGGATTACC
TGAGGATGTTAAAGAATACTTCACAGCACGTTATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A376IXW9

Antitoxin

Source ID Structure
AlphaFold DB A0A376IZ90

References