Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1334948..1335602 Replicon chromosome
Accession NZ_CP065624
Organism Escherichia coli strain FDAARGOS_941

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag I6G98_RS07640 Protein ID WP_197932940.1
Coordinates 1334948..1335355 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag I6G98_RS07645 Protein ID WP_000354046.1
Coordinates 1335336..1335602 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6G98_RS07620 1330906..1332639 - 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -
I6G98_RS07625 1332645..1333355 - 711 WP_032359753.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6G98_RS07630 1333379..1334275 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
I6G98_RS07635 1334387..1334908 + 522 WP_197932939.1 flavodoxin FldB -
I6G98_RS07640 1334948..1335355 - 408 WP_197932940.1 protein YgfX Toxin
I6G98_RS07645 1335336..1335602 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
I6G98_RS07650 1335845..1336825 + 981 WP_032359755.1 tRNA-modifying protein YgfZ -
I6G98_RS07655 1337021..1337680 - 660 WP_032359756.1 hemolysin III family protein -
I6G98_RS07660 1337844..1338155 - 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
I6G98_RS07665 1338200..1339633 + 1434 WP_032359762.1 6-phospho-beta-glucosidase BglA -
I6G98_RS07670 1339690..1340433 - 744 WP_000951948.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.2669

>T183066 WP_197932940.1 NZ_CP065624:c1335355-1334948 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLWRILLQQETQR

Download         Length: 408 bp

>T183066 NZ_CP086627:c4451427-4451140 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT183066 WP_000354046.1 NZ_CP065624:c1335602-1335336 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT183066 NZ_CP086627:c4451153-4450851 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References