Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1855451..1856283 Replicon chromosome
Accession NZ_CP065613
Organism Escherichia coli strain FDAARGOS_944

Toxin (Protein)


Gene name yeeV Uniprot ID A0A377CTL9
Locus tag I6H01_RS09035 Protein ID WP_038339830.1
Coordinates 1855909..1856283 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A377CT47
Locus tag I6H01_RS09030 Protein ID WP_038339831.1
Coordinates 1855451..1855819 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H01_RS09000 1852016..1852470 + 455 Protein_1755 hypothetical protein -
I6H01_RS09005 1852571..1852774 + 204 WP_038339834.1 DUF905 family protein -
I6H01_RS09010 1852876..1853697 + 822 WP_038339833.1 DUF945 domain-containing protein -
I6H01_RS09015 1854039..1854512 + 474 WP_001387789.1 antirestriction protein -
I6H01_RS09020 1854528..1855004 + 477 WP_038339832.1 RadC family protein -
I6H01_RS09025 1855067..1855288 + 222 WP_000692345.1 DUF987 domain-containing protein -
I6H01_RS09030 1855451..1855819 + 369 WP_038339831.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
I6H01_RS09035 1855909..1856283 + 375 WP_038339830.1 TA system toxin CbtA family protein Toxin
I6H01_RS09040 1856280..1856768 + 489 WP_038339829.1 hypothetical protein -
I6H01_RS09045 1856788..1856976 + 189 WP_038339828.1 DUF957 domain-containing protein -
I6H01_RS09050 1857061..1857903 + 843 WP_038339827.1 DUF4942 domain-containing protein -
I6H01_RS09055 1858184..1858720 - 537 WP_038339826.1 GspM family type II secretion system protein YghD -
I6H01_RS09060 1858722..1859900 - 1179 WP_038339825.1 type II secretion system protein GspL -
I6H01_RS09065 1859897..1860874 - 978 WP_038339824.1 type II secretion system minor pseudopilin GspK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14102.12 Da        Isoelectric Point: 8.2905

>T183017 WP_038339830.1 NZ_CP065613:1855909-1856283 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T183017 NZ_CP086625:c4658666-4658316 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13520.42 Da        Isoelectric Point: 6.9554

>AT183017 WP_038339831.1 NZ_CP065613:1855451-1855819 [Escherichia coli]
VSDTLSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT183017 NZ_CP086625:c4658911-4658660 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377CTL9

Antitoxin

Source ID Structure
AlphaFold DB A0A377CT47

References