Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 660123..660607 Replicon chromosome
Accession NZ_CP065613
Organism Escherichia coli strain FDAARGOS_944

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag I6H01_RS03430 Protein ID WP_014334020.1
Coordinates 660317..660607 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A377E9X9
Locus tag I6H01_RS03425 Protein ID WP_038338941.1
Coordinates 660123..660317 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H01_RS03380 655232..655648 - 417 WP_005069274.1 hypothetical protein -
I6H01_RS03385 655745..656200 - 456 WP_000335375.1 ead/Ea22-like family protein -
I6H01_RS03390 656187..656492 - 306 WP_001266147.1 DUF4406 domain-containing protein -
I6H01_RS03395 656489..656911 - 423 WP_001151146.1 DUF977 family protein -
I6H01_RS03400 656952..658061 - 1110 WP_038338940.1 DNA-binding protein -
I6H01_RS03405 658141..658599 + 459 WP_073801390.1 hypothetical protein -
I6H01_RS03410 658806..659231 - 426 WP_000693902.1 Rha family transcriptional regulator -
I6H01_RS03415 659228..659491 - 264 WP_001048455.1 helix-turn-helix domain-containing protein -
I6H01_RS03420 659603..660103 + 501 WP_001343764.1 helix-turn-helix domain-containing protein -
I6H01_RS03425 660123..660317 + 195 WP_038338941.1 hypothetical protein Antitoxin
I6H01_RS03430 660317..660607 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H01_RS03435 660883..661038 + 156 WP_072035477.1 DUF1391 family protein -
I6H01_RS03440 661198..661416 + 219 WP_038338945.1 hypothetical protein -
I6H01_RS03445 661985..662173 + 189 WP_000854564.1 cell division inhibition protein DicB -
I6H01_RS03450 662170..662358 + 189 WP_001070253.1 DUF1482 family protein -
I6H01_RS03455 662452..664893 + 2442 WP_038338946.1 exonuclease -
I6H01_RS03460 664952..665155 + 204 WP_000096344.1 DUF4224 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - ipaH9.8 622592..667651 45059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T183011 WP_014334020.1 NZ_CP065613:660317-660607 [Escherichia coli]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T183011 NZ_CP086625:3208203-3208697 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7138.00 Da        Isoelectric Point: 4.3321

>AT183011 WP_038338941.1 NZ_CP065613:660123-660317 [Escherichia coli]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADHRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT183011 NZ_CP086625:3207913-3208206 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAACCAGGCGCGAATCTTTAAATTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A377E9X9

References