Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1838922..1839676 Replicon chromosome
Accession NZ_CP065607
Organism Escherichia coli strain FDAARGOS_946

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag I6H03_RS09555 Protein ID WP_001301452.1
Coordinates 1839191..1839676 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag I6H03_RS09550 Protein ID WP_000801912.1
Coordinates 1838922..1839200 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H03_RS09545 1836150..1838855 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
I6H03_RS09550 1838922..1839200 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
I6H03_RS09555 1839191..1839676 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
I6H03_RS09560 1839726..1840754 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
I6H03_RS09565 1840758..1841984 - 1227 WP_001105474.1 RNA-splicing ligase RtcB -
I6H03_RS09570 1842172..1843770 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
I6H03_RS09575 1843752..1844510 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T182960 WP_001301452.1 NZ_CP065607:1839191-1839676 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T182960 NZ_CP086623:3057569-3057676 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT182960 WP_000801912.1 NZ_CP065607:1838922-1839200 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp

>AT182960 NZ_CP086623:c3057519-3057456 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References