Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
Location | 1838922..1839676 | Replicon | chromosome |
Accession | NZ_CP065607 | ||
Organism | Escherichia coli strain FDAARGOS_946 |
Toxin (Protein)
Gene name | ataT | Uniprot ID | - |
Locus tag | I6H03_RS09555 | Protein ID | WP_001301452.1 |
Coordinates | 1839191..1839676 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | ataR | Uniprot ID | Q8X700 |
Locus tag | I6H03_RS09550 | Protein ID | WP_000801912.1 |
Coordinates | 1838922..1839200 (+) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6H03_RS09545 | 1836150..1838855 | + | 2706 | WP_000906970.1 | HTH-type transcriptional regulator MalT | - |
I6H03_RS09550 | 1838922..1839200 | + | 279 | WP_000801912.1 | DUF1778 domain-containing protein | Antitoxin |
I6H03_RS09555 | 1839191..1839676 | + | 486 | WP_001301452.1 | GNAT family N-acetyltransferase | Toxin |
I6H03_RS09560 | 1839726..1840754 | - | 1029 | WP_000827117.1 | RNA 3'-terminal phosphate cyclase | - |
I6H03_RS09565 | 1840758..1841984 | - | 1227 | WP_001105474.1 | RNA-splicing ligase RtcB | - |
I6H03_RS09570 | 1842172..1843770 | + | 1599 | WP_001232889.1 | DNA-binding transcriptional regulator RtcR | - |
I6H03_RS09575 | 1843752..1844510 | - | 759 | WP_001302007.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17650.57 Da Isoelectric Point: 9.4066
>T182960 WP_001301452.1 NZ_CP065607:1839191-1839676 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E
Download Length: 486 bp
>T182960 NZ_CP086623:3057569-3057676 [Escherichia coli]
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCACGCAGTTTGCCATGACTTTCTGGCACGACTTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10420.94 Da Isoelectric Point: 4.6336
>AT182960 WP_000801912.1 NZ_CP065607:1838922-1839200 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE
Download Length: 279 bp
>AT182960 NZ_CP086623:c3057519-3057456 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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