Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 30267..30814 Replicon plasmid unnamed1
Accession NZ_CP065606
Organism Escherichia coli strain FDAARGOS_946

Toxin (Protein)


Gene name parE Uniprot ID A0A896ZGX1
Locus tag I6H03_RS00170 Protein ID WP_000969997.1
Coordinates 30267..30548 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A7U8WKC6
Locus tag I6H03_RS00175 Protein ID WP_000079946.1
Coordinates 30545..30814 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H03_RS00150 26268..27614 - 1347 WP_001132032.1 hypothetical protein -
I6H03_RS00155 27968..28561 + 594 WP_000517696.1 hypothetical protein -
I6H03_RS00160 28843..29430 - 588 WP_001418189.1 serine acetyltransferase -
I6H03_RS00165 29730..30071 + 342 WP_000578011.1 hypothetical protein -
I6H03_RS00170 30267..30548 - 282 WP_000969997.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H03_RS00175 30545..30814 - 270 WP_000079946.1 hypothetical protein Antitoxin
I6H03_RS00180 30869..31027 - 159 WP_000829588.1 hypothetical protein -
I6H03_RS00185 31729..31836 - 108 Protein_36 incFII family plasmid replication initiator RepA -
I6H03_RS00190 31859..32107 - 249 WP_000083841.1 replication regulatory protein RepA -
I6H03_RS00195 32336..32629 - 294 Protein_38 hypothetical protein -
I6H03_RS00200 32928..33143 - 216 Protein_39 IS3 family transposase -
I6H03_RS00205 33218..33619 - 402 WP_001222321.1 GspS family T2SS pilot lipoprotein variant EptO -
I6H03_RS00210 33713..34546 - 834 WP_000088803.1 A24 family peptidase -
I6H03_RS00215 34598..35113 - 516 WP_000998852.1 type II secretion system protein M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - nleA/espI / exeG / exeE / stcE 1..66104 66104


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10879.54 Da        Isoelectric Point: 8.4615

>T182946 WP_000969997.1 NZ_CP065606:c30548-30267 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YVLRVLHTAQKWP

Download         Length: 282 bp

>T182946 NZ_CP086623:207428-207613 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10210.55 Da        Isoelectric Point: 8.8735

>AT182946 WP_000079946.1 NZ_CP065606:c30814-30545 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLGRGDVLPHDMVESSATAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT182946 NZ_CP086623:207630-208040 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGTGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A896ZGX1

Antitoxin

Source ID Structure
AlphaFold DB A0A7U8WKC6

References