Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 922681..923215 Replicon chromosome
Accession NZ_CP065604
Organism Aggregatibacter actinomycetemcomitans strain FDAARGOS_948

Toxin (Protein)


Gene name relE Uniprot ID A0A142FYB7
Locus tag I6H05_RS04315 Protein ID WP_005540089.1
Coordinates 922925..923215 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6H05_RS04310 Protein ID WP_005545663.1
Coordinates 922681..922935 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H05_RS04280 918406..919503 + 1098 WP_005567586.1 histidinol-phosphate transaminase -
I6H05_RS04285 919514..920845 + 1332 WP_005594223.1 3-phosphoshikimate 1-carboxyvinyltransferase -
I6H05_RS04290 920933..921400 - 468 WP_005565412.1 ribonuclease HI -
I6H05_RS04295 921468..922229 + 762 WP_005567590.1 DNA polymerase III subunit epsilon -
I6H05_RS04310 922681..922935 + 255 WP_005545663.1 stability protein StbD Antitoxin
I6H05_RS04315 922925..923215 + 291 WP_005540089.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H05_RS04320 923272..923610 - 339 WP_005540087.1 cupin domain-containing protein -
I6H05_RS04325 923951..924403 + 453 WP_006710245.1 50S ribosomal protein L11 methyltransferase -
I6H05_RS04330 924574..925962 + 1389 WP_005567594.1 tRNA 5-hydroxyuridine modification protein YegQ -
I6H05_RS04335 926259..927350 + 1092 WP_005545654.1 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11509.34 Da        Isoelectric Point: 10.7396

>T182944 WP_005540089.1 NZ_CP065604:922925-923215 [Aggregatibacter actinomycetemcomitans]
MTYKLTFDKRALKEWQKLGDTIRQQFKNKLAERLENPRVPGDKLRGYQNLYKIKLRAAGYRLVYEVNDNQIYILVLSVGK
RNRLDAYKNAEFRQAR

Download         Length: 291 bp

>T182944 NZ_CP086622:c5059718-5059407 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTCACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9294.53 Da        Isoelectric Point: 3.9649

>AT182944 WP_005545663.1 NZ_CP065604:922681-922935 [Aggregatibacter actinomycetemcomitans]
MAIHQILTQQAASITDLKRDPMGIAYASQDGAVAILNRNQPAFYCVTPALFEYFQNLVEDAELGRIAEERLATLDPIEVS
LDDL

Download         Length: 255 bp

>AT182944 NZ_CP086622:c5059406-5059116 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A142FYB7

Antitoxin

Source ID Structure

References