Detailed information of TA system TA182942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM-YoeB
• Location: 839784..840286
• Replicon: chromosome
• Accession: NZ_CP065604
• Organism: Aggregatibacter actinomycetemcomitans strain FDAARGOS_948

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JX79
• Locus tag: I6H05_RS03970
• Protein ID: WP_005547296.1
• Coordinates: 839784..840035 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JRQ5
• Locus tag: I6H05_RS03975
• Protein ID: WP_025298489.1
• Coordinates: 840032..840286 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H05_RS03950	835090..836283	-	1194	WP_005556328.1	hypothetical protein	-
I6H05_RS03955	836292..837065	-	774	WP_025298488.1	glycosyltransferase family 25 protein	-
I6H05_RS03960	837199..838722	+	1524	WP_005567290.1	polysaccharide biosynthesis protein	-
I6H05_RS03965	838719..839675	+	957	WP_005556319.1	polysaccharide pyruvyl transferase family protein	-
I6H05_RS03970	839784..840035	+	252	WP_005547296.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Toxin
I6H05_RS03975	840032..840286	+	255	WP_025298489.1	Txe/YoeB family addiction module toxin	Antitoxin
I6H05_RS03980	840299..841042	+	744	WP_025298490.1	YdcF family protein	-
I6H05_RS03985	841219..842046	+	828	WP_005556311.1	DNA ligase	-
I6H05_RS03990	842179..844353	-	2175	WP_005556309.1	DNA helicase II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Antitoxin

• Toxin YoeB (5-84)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9394.66 Da
• Isoelectric Point: 5.0637

>T182942 WP_005547296.1 NZ_CP065604:839784-840035 [Aggregatibacter actinomycetemcomitans]
MNVISYSAFRAELATTLDQVVADHSPVMITRQNGKHAVVMSLEDFAAYEETAYLLRSPKNRERLLASIDQLNSGKIIERE
LQE

Nucleotide

• Length: 252 bp

>T182942 NZ_CP086622:c4666643-4666293 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGTGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 10216.77 Da
• Isoelectric Point: 9.7542

>AT182942 WP_025298489.1 NZ_CP065604:840032-840286 [Aggregatibacter actinomycetemcomitans]
MILAWTETAWEDYLYWQQVDKKTLLRINKLIQNITRSPFEGLGNPKPLKHQLSGFWSRRIDKEHRLVYQVSDSHLTIIQC
RYHY

Nucleotide

• Length: 255 bp

>AT182942 NZ_CP086622:c4666888-4666637 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: X2JX79

Antitoxin

• AlphaFold DB: X2JRQ5