Detailed information of TA system TA182940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 277913..278463
• Replicon: chromosome
• Accession: NZ_CP065604
• Organism: Aggregatibacter actinomycetemcomitans strain FDAARGOS_948

Toxin (Protein)

• Gene name: relE
• Uniprot ID: X2JVL6
• Locus tag: I6H05_RS01380
• Protein ID: WP_005545988.1
• Coordinates: 277913..278179 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: X2JQ67
• Locus tag: I6H05_RS01385
• Protein ID: WP_005539223.1
• Coordinates: 278191..278463 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6H05_RS01345	273540..274001	-	462	Protein_258	hypothetical protein	-
I6H05_RS01350	274092..274757	-	666	WP_005567468.1	helix-turn-helix domain-containing protein	-
I6H05_RS01355	274858..275097	+	240	WP_005567469.1	hypothetical protein	-
I6H05_RS01360	275124..275315	+	192	Protein_261	phage head protein	-
I6H05_RS01365	275581..275997	+	417	WP_025298349.1	hypothetical protein	-
I6H05_RS01370	275997..276116	-	120	Protein_263	DUF4102 domain-containing protein	-
I6H05_RS01375	276322..277881	-	1560	WP_005545986.1	glutamine-hydrolyzing GMP synthase	-
I6H05_RS01380	277913..278179	-	267	WP_005545988.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I6H05_RS01385	278191..278463	-	273	WP_005539223.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6H05_RS01390	278718..280070	-	1353	WP_025298350.1	anaerobic C4-dicarboxylate transporter DcuC	-
I6H05_RS01400	280509..280964	+	456	WP_005545995.1	ribosome maturation factor RimP	-
I6H05_RS01405	280988..282484	+	1497	WP_005567486.1	transcription termination/antitermination protein NusA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-88)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-85)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10516.05 Da
• Isoelectric Point: 7.2393

>T182940 WP_005545988.1 NZ_CP065604:c278179-277913 [Aggregatibacter actinomycetemcomitans]
MDYVLSKEYKRDLKKLPVEIQSGPEYAEVLYCLFNQKSLPERYKDHALQGNWQGFRDCHIKNDLILIYKIEADTLYFARL
NSHSEVFK

Nucleotide

• Length: 267 bp

>T182940 NZ_CP086622:c4175103-4174705 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10147.52 Da
• Isoelectric Point: 6.2633

>AT182940 WP_005539223.1 NZ_CP065604:c278463-278191 [Aggregatibacter actinomycetemcomitans]
MLDSAVNFRTQADIKEQAFNVIKSYGLTPAQVLNMFLTQIAKTNTIPLSLDYQPNTKTANAINELMSGKGERFSVDSFDE
FQQKIRDLSK

Nucleotide

• Length: 273 bp

>AT182940 NZ_CP086622:c4175399-4175106 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAATCCAGCAAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAACTGGTGAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: X2JVL6

Antitoxin

• AlphaFold DB: X2JQ67