Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/COG3657-dnstrm_HI1420
Location 118638..119230 Replicon chromosome
Accession NZ_CP065604
Organism Aggregatibacter actinomycetemcomitans strain FDAARGOS_948

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6H05_RS00565 Protein ID WP_014167707.1
Coordinates 118638..118937 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6H05_RS00570 Protein ID WP_005568148.1
Coordinates 118934..119230 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6H05_RS00540 113917..115131 - 1215 WP_014167705.1 molybdopterin molybdotransferase MoeA -
I6H05_RS00545 115260..115916 + 657 WP_025298303.1 GTP cyclohydrolase I FolE -
I6H05_RS00550 116017..117459 - 1443 WP_005568153.1 serine-type D-Ala-D-Ala carboxypeptidase -
I6H05_RS00555 117619..118095 + 477 WP_005568152.1 transcription elongation factor GreA -
I6H05_RS00560 118168..118470 - 303 WP_005568150.1 ribosome assembly RNA-binding protein YhbY -
I6H05_RS00565 118638..118937 + 300 WP_014167707.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6H05_RS00570 118934..119230 + 297 WP_005568148.1 putative addiction module antidote protein Antitoxin
I6H05_RS00575 119263..119877 - 615 WP_005568146.1 riboflavin synthase -
I6H05_RS00580 119904..121301 + 1398 WP_005568144.1 MATE family efflux transporter -
I6H05_RS00585 121605..122084 - 480 WP_025298305.1 Cys-tRNA(Pro) deacylase -
I6H05_RS00590 122145..122948 + 804 WP_025298306.1 aspartate-semialdehyde dehydrogenase -
I6H05_RS00595 122903..123382 + 480 Protein_112 extracellular solute-binding protein -
I6H05_RS00600 123357..124154 + 798 WP_005568139.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-92)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11406.53 Da        Isoelectric Point: 10.6671

>T182938 WP_014167707.1 NZ_CP065604:118638-118937 [Aggregatibacter actinomycetemcomitans]
MMIQIKTTFLFDEWLKKLKNLRAKAKINARIKRLQFGNFGDLKSVNDGIFEMRIDKGQGYRVYLKNQNGILVILLCGGDK
STQEKDIKKAKQLAQEMGL

Download         Length: 300 bp

>T182938 NZ_CP086622:3954811-3955029 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10939.44 Da        Isoelectric Point: 4.4155

>AT182938 WP_005568148.1 NZ_CP065604:118934-119230 [Aggregatibacter actinomycetemcomitans]
MSEQLKDFDPAEYLSTEEDIRLYLNEVLQENNIELILSALGDIARTRNMSQIARETGMSREGLYKALSGTGNPTFATVIK
VMKALNLQLQVQPSGYVS

Download         Length: 297 bp

>AT182938 NZ_CP086622:3954411-3954785 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References